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Preventive effects of lansoprazole and famotidine on gastric mucosal injury induced by low-dose aspirin in Helicobacter pylori-negative healthy volunteers.
Nishino M, Sugimoto M, Kodaira C, Yamade M, Uotani T, Shirai N, Ikuma M, Tanaka T, Sugimura H, Hishida A, Furuta T. Nishino M, et al. Among authors: uotani t. J Clin Pharmacol. 2011 Jul;51(7):1079-86. doi: 10.1177/0091270010376194. Epub 2010 Jul 27. J Clin Pharmacol. 2011. PMID: 20663999 Clinical Trial.
Rabeprazole 10 mg q.d.s. decreases 24-h intragastric acidity significantly more than rabeprazole 20 mg b.d. or 40 mg o.m., overcoming CYP2C19 genotype.
Sugimoto M, Shirai N, Nishino M, Kodaira C, Uotani T, Yamade M, Sahara S, Ichikawa H, Sugimoto K, Miyajima H, Furuta T. Sugimoto M, et al. Among authors: uotani t. Aliment Pharmacol Ther. 2012 Oct;36(7):627-34. doi: 10.1111/apt.12014. Epub 2012 Aug 10. Aliment Pharmacol Ther. 2012. PMID: 22882464 Free article.
Twice-daily dosing of esomeprazole effectively inhibits acid secretion in CYP2C19 rapid metabolisers compared with twice-daily omeprazole, rabeprazole or lansoprazole.
Sahara S, Sugimoto M, Uotani T, Ichikawa H, Yamade M, Iwaizumi M, Yamada T, Osawa S, Sugimoto K, Umemura K, Miyajima H, Furuta T. Sahara S, et al. Among authors: uotani t. Aliment Pharmacol Ther. 2013 Nov;38(9):1129-37. doi: 10.1111/apt.12492. Epub 2013 Sep 16. Aliment Pharmacol Ther. 2013. PMID: 24099474 Free article. Clinical Trial.
Ability of rabeprazole to prevent gastric mucosal damage from clopidogrel and low doses of aspirin depends on CYP2C19 genotype.
Uotani T, Sugimoto M, Nishino M, Kodaira C, Yamade M, Sahara S, Yamada T, Osawa S, Sugimoto K, Tanaka T, Umemura K, Watanabe H, Miyajima H, Furuta T. Uotani T, et al. Clin Gastroenterol Hepatol. 2012 Aug;10(8):879-885.e2. doi: 10.1016/j.cgh.2012.04.016. Epub 2012 Apr 25. Clin Gastroenterol Hepatol. 2012. PMID: 22542748 Clinical Trial.
Antiplatelet drugs are a risk factor for esophageal mucosal injury.
Sugimoto M, Uotani T, Nishino M, Yamade M, Sahara S, Yamada T, Osawa S, Sugimoto K, Umemura K, Watanabe H, Miyajima H, Furuta T. Sugimoto M, et al. Among authors: uotani t. Digestion. 2013;87(4):281-9. doi: 10.1159/000350438. Epub 2013 Jun 13. Digestion. 2013. PMID: 23774797
83 results