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Inhibition of interleukin-1beta converting enzyme (ICE or caspase 1) by aspartyl acyloxyalkyl ketones and aspartyl amidooxyalkyl ketones.
Galatsis P, Caprathe B, Downing D, Gilmore J, Harter W, Hays S, Kostlan C, Linn K, Lunney E, Para K, Thomas A, Warmus J, Allen H, Brady K, Talanian R, Walker N. Galatsis P, et al. Among authors: allen h. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5089-94. doi: 10.1016/j.bmcl.2010.07.031. Epub 2010 Jul 11. Bioorg Med Chem Lett. 2010. PMID: 20674352
Structure-based design of caspase-1 inhibitor containing a diphenyl ether sulfonamide.
Shahripour AB, Plummer MS, Lunney EA, Sawyer TK, Stankovic CJ, Connolly MK, Rubin JR, Walker NP, Brady KD, Allen HJ, Talanian RV, Wong WW, Humblet C. Shahripour AB, et al. Among authors: allen hj. Bioorg Med Chem Lett. 2001 Oct 22;11(20):2779-82. doi: 10.1016/s0960-894x(01)00573-x. Bioorg Med Chem Lett. 2001. PMID: 11591522
Non-erythroid alpha-spectrin breakdown by calpain and interleukin 1 beta-converting-enzyme-like protease(s) in apoptotic cells: contributory roles of both protease families in neuronal apoptosis.
Nath R, Raser KJ, Stafford D, Hajimohammadreza I, Posner A, Allen H, Talanian RV, Yuen P, Gilbertsen RB, Wang KK. Nath R, et al. Among authors: allen h. Biochem J. 1996 Nov 1;319 ( Pt 3)(Pt 3):683-90. doi: 10.1042/bj3190683. Biochem J. 1996. PMID: 8920967 Free PMC article.
Discovery of thieno[2,3-c]pyridines as potent COT inhibitors.
George D, Friedman M, Allen H, Argiriadi M, Barberis C, Bischoff A, Clabbers A, Cusack K, Dixon R, Fix-Stenzel S, Gordon T, Janssen B, Jia Y, Moskey M, Quinn C, Salmeron JA, Wishart N, Woller K, Yu Z. George D, et al. Among authors: allen h. Bioorg Med Chem Lett. 2008 Sep 15;18(18):4952-5. doi: 10.1016/j.bmcl.2008.08.037. Epub 2008 Aug 14. Bioorg Med Chem Lett. 2008. PMID: 18755587
1,542 results