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Design, synthesis, and biological evaluation of new monoamine reuptake inhibitors with potential therapeutic utility in depression and pain.
Lucas MC, Weikert RJ, Carter DS, Cai HY, Greenhouse R, Iyer PS, Lin CJ, Lee EK, Madera AM, Moore A, Ozboya K, Schoenfeld RC, Steiner S, Zhai Y, Lynch SM. Lucas MC, et al. Among authors: iyer ps. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5559-66. doi: 10.1016/j.bmcl.2010.07.020. Epub 2010 Aug 4. Bioorg Med Chem Lett. 2010. PMID: 20691589
Novel 3,3-disubstituted pyrrolidines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors.
Bannwart LM, Carter DS, Cai HY, Choy JC, Greenhouse R, Jaime-Figueroa S, Iyer PS, Lin CJ, Lee EK, Lucas MC, Lynch SM, Madera AM, Moore A, Ozboya K, Raptova L, Roetz R, Schoenfeld RC, Stein KA, Steiner S, Villa M, Weikert RJ, Zhai Y. Bannwart LM, et al. Among authors: iyer ps. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6062-6. doi: 10.1016/j.bmcl.2008.10.025. Epub 2008 Oct 11. Bioorg Med Chem Lett. 2008. PMID: 18954985
Novel, achiral aminoheterocycles as selective monoamine reuptake inhibitors.
Lucas MC, Carter DS, Cai HY, Lee EK, Schoenfeld RC, Steiner S, Villa M, Weikert RJ, Iyer PS. Lucas MC, et al. Among authors: iyer ps. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4630-3. doi: 10.1016/j.bmcl.2009.06.076. Epub 2009 Jun 25. Bioorg Med Chem Lett. 2009. PMID: 19592243
Discovery of a novel series of 4-quinolone JNK inhibitors.
Gong L, Tan YC, Boice G, Abbot S, McCaleb K, Iyer P, Zuo F, Dal Porto J, Wong B, Jin S, Chang A, Tran P, Hsieh G, Niu L, Shao A, Reuter D, Lukacs CM, Ursula Kammlott R, Kuglstatter A, Goldstein D. Gong L, et al. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7381-7. doi: 10.1016/j.bmcl.2012.10.066. Epub 2012 Oct 24. Bioorg Med Chem Lett. 2012. PMID: 23142618
Discovery of novel PI3-kinase δ specific inhibitors for the treatment of rheumatoid arthritis: taming CYP3A4 time-dependent inhibition.
Safina BS, Baker S, Baumgardner M, Blaney PM, Chan BK, Chen YH, Cartwright MW, Castanedo G, Chabot C, Cheguillaume AJ, Goldsmith P, Goldstein DM, Goyal B, Hancox T, Handa RK, Iyer PS, Kaur J, Kondru R, Kenny JR, Krintel SL, Li J, Lesnick J, Lucas MC, Lewis C, Mukadam S, Murray J, Nadin AJ, Nonomiya J, Padilla F, Palmer WS, Pang J, Pegg N, Price S, Reif K, Salphati L, Savy PA, Seward EM, Shuttleworth S, Sohal S, Sweeney ZK, Tay S, Tivitmahaisoon P, Waszkowycz B, Wei B, Yue Q, Zhang C, Sutherlin DP. Safina BS, et al. Among authors: iyer ps. J Med Chem. 2012 Jun 28;55(12):5887-900. doi: 10.1021/jm3003747. Epub 2012 Jun 11. J Med Chem. 2012. PMID: 22626259
Azaindoles: noncovalent DprE1 inhibitors from scaffold morphing efforts, kill Mycobacterium tuberculosis and are efficacious in vivo.
Shirude PS, Shandil R, Sadler C, Naik M, Hosagrahara V, Hameed S, Shinde V, Bathula C, Humnabadkar V, Kumar N, Reddy J, Panduga V, Sharma S, Ambady A, Hegde N, Whiteaker J, McLaughlin RE, Gardner H, Madhavapeddi P, Ramachandran V, Kaur P, Narayan A, Guptha S, Awasthy D, Narayan C, Mahadevaswamy J, Vishwas KG, Ahuja V, Srivastava A, Prabhakar KR, Bharath S, Kale R, Ramaiah M, Choudhury NR, Sambandamurthy VK, Solapure S, Iyer PS, Narayanan S, Chatterji M. Shirude PS, et al. Among authors: iyer ps. J Med Chem. 2013 Dec 12;56(23):9701-8. doi: 10.1021/jm401382v. Epub 2013 Nov 21. J Med Chem. 2013. PMID: 24215368
Development of potent and selective Cathepsin C inhibitors free of aortic binding liability by application of a conformational restriction strategy.
Banerjee A, Velagaleti R, Patil S, Pawar M, Yadav P, Kadam P, Qadri MM, Chakraborti S, Saini JS, Behera DB, Karanjai K, Iyer PS, Gharat LA, Das S. Banerjee A, et al. Among authors: iyer ps. Bioorg Med Chem Lett. 2021 Sep 1;47:128202. doi: 10.1016/j.bmcl.2021.128202. Epub 2021 Jun 15. Bioorg Med Chem Lett. 2021. PMID: 34139325
74 results