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Discovery of a potent and selective noncovalent linear inhibitor of the hepatitis C virus NS3 protease (BI 201335).
Llinàs-Brunet M, Bailey MD, Goudreau N, Bhardwaj PK, Bordeleau J, Bös M, Bousquet Y, Cordingley MG, Duan J, Forgione P, Garneau M, Ghiro E, Gorys V, Goulet S, Halmos T, Kawai SH, Naud J, Poupart MA, White PW. Llinàs-Brunet M, et al. Among authors: goulet s. J Med Chem. 2010 Sep 9;53(17):6466-76. doi: 10.1021/jm100690x. J Med Chem. 2010. PMID: 20715823
Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors.
Stammers TA, Coulombe R, Rancourt J, Thavonekham B, Fazal G, Goulet S, Jakalian A, Wernic D, Tsantrizos Y, Poupart MA, Bös M, McKercher G, Thauvette L, Kukolj G, Beaulieu PL. Stammers TA, et al. Among authors: goulet s. Bioorg Med Chem Lett. 2013 May 1;23(9):2585-9. doi: 10.1016/j.bmcl.2013.02.110. Epub 2013 Mar 7. Bioorg Med Chem Lett. 2013. PMID: 23545108
Optimization of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of HIV capsid assembly inhibitors 2: structure-activity relationships (SAR) of the C3-phenyl moiety.
Fader LD, Landry S, Goulet S, Morin S, Kawai SH, Bousquet Y, Dion I, Hucke O, Goudreau N, Lemke CT, Rancourt J, Bonneau P, Titolo S, Amad M, Garneau M, Duan J, Mason S, Simoneau B. Fader LD, et al. Among authors: goulet s. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3401-5. doi: 10.1016/j.bmcl.2013.03.074. Epub 2013 Apr 3. Bioorg Med Chem Lett. 2013. PMID: 23601710
Peptidomimetic inhibitors of the human cytomegalovirus protease.
Ogilvie W, Bailey M, Poupart MA, Abraham A, Bhavsar A, Bonneau P, Bordeleau J, Bousquet Y, Chabot C, Duceppe JS, Fazal G, Goulet S, Grand-Maître C, Guse I, Halmos T, Lavallée P, Leach M, Malenfant E, O'Meara J, Plante R, Plouffe C, Poirier M, Soucy F, Yoakim C, Déziel R. Ogilvie W, et al. Among authors: goulet s. J Med Chem. 1997 Dec 5;40(25):4113-35. doi: 10.1021/jm970104t. J Med Chem. 1997. PMID: 9406601
Peptide-based inhibitors of the hepatitis C virus serine protease.
Llinàs-Brunet M, Bailey M, Fazal G, Goulet S, Halmos T, Laplante S, Maurice R, Poirier M, Poupart MA, Thibeault D, Wernic D, Lamarre D. Llinàs-Brunet M, et al. Among authors: goulet s. Bioorg Med Chem Lett. 1998 Jul 7;8(13):1713-8. doi: 10.1016/s0960-894x(98)00299-6. Bioorg Med Chem Lett. 1998. PMID: 9873421
86 results