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89 results

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Page 1
Discovery of a potent and selective noncovalent linear inhibitor of the hepatitis C virus NS3 protease (BI 201335).
Llinàs-Brunet M, Bailey MD, Goudreau N, Bhardwaj PK, Bordeleau J, Bös M, Bousquet Y, Cordingley MG, Duan J, Forgione P, Garneau M, Ghiro E, Gorys V, Goulet S, Halmos T, Kawai SH, Naud J, Poupart MA, White PW. Llinàs-Brunet M, et al. Among authors: naud j. J Med Chem. 2010 Sep 9;53(17):6466-76. doi: 10.1021/jm100690x. J Med Chem. 2010. PMID: 20715823
Novel 8-substituted dipyridodiazepinone inhibitors with a broad-spectrum of activity against HIV-1 strains resistant to non-nucleoside reverse transcriptase inhibitors.
O'Meara JA, Yoakim C, Bonneau PR, Bös M, Cordingley MG, Déziel R, Doyon L, Duan J, Garneau M, Guse I, Landry S, Malenfant E, Naud J, Ogilvie WW, Thavonekham B, Simoneau B. O'Meara JA, et al. Among authors: naud j. J Med Chem. 2005 Aug 25;48(17):5580-8. doi: 10.1021/jm050255t. J Med Chem. 2005. PMID: 16107158
Optimization and determination of the absolute configuration of a series of potent inhibitors of human papillomavirus type-11 E1-E2 protein-protein interaction: a combined medicinal chemistry, NMR and computational chemistry approach.
Goudreau N, Cameron DR, Déziel R, Haché B, Jakalian A, Malenfant E, Naud J, Ogilvie WW, O'meara J, White PW, Yoakim C. Goudreau N, et al. Among authors: naud j. Bioorg Med Chem. 2007 Apr 1;15(7):2690-700. doi: 10.1016/j.bmc.2007.01.036. Epub 2007 Jan 24. Bioorg Med Chem. 2007. PMID: 17306550
Potent triazolyl-proline-based inhibitors of HCV NS3 protease.
Naud J, Lemke C, Goudreau N, Beaulieu E, White PD, Llinàs-Brunet M, Forgione P. Naud J, et al. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3400-4. doi: 10.1016/j.bmcl.2008.04.012. Epub 2008 Apr 10. Bioorg Med Chem Lett. 2008. PMID: 18448339
Synthesis and optimization of a novel series of HCV NS3 protease inhibitors: 4-arylproline analogs.
Bilodeau F, Bailey MD, Bhardwaj PK, Bordeleau J, Forgione P, Garneau M, Ghiro E, Gorys V, Halmos T, Jolicoeur ES, Leblanc M, Lemke CT, Naud J, O'Meara J, White PW, Llinàs-Brunet M. Bilodeau F, et al. Among authors: naud j. Bioorg Med Chem Lett. 2013 Jul 15;23(14):4267-71. doi: 10.1016/j.bmcl.2013.03.043. Epub 2013 Mar 19. Bioorg Med Chem Lett. 2013. PMID: 23735741
Structure-based design of novel HCV NS5B thumb pocket 2 allosteric inhibitors with submicromolar gt1 replicon potency: discovery of a quinazolinone chemotype.
Beaulieu PL, Coulombe R, Duan J, Fazal G, Godbout C, Hucke O, Jakalian A, Joly MA, Lepage O, Llinàs-Brunet M, Naud J, Poirier M, Rioux N, Thavonekham B, Kukolj G, Stammers TA. Beaulieu PL, et al. Among authors: naud j. Bioorg Med Chem Lett. 2013 Jul 15;23(14):4132-40. doi: 10.1016/j.bmcl.2013.05.037. Epub 2013 May 23. Bioorg Med Chem Lett. 2013. PMID: 23768906
Novel nevirapine-like inhibitors with improved activity against NNRTI-resistant HIV: 8-heteroarylthiomethyldipyridodiazepinone derivatives.
Yoakim C, Bonneau PR, Déziel R, Doyon L, Duan J, Guse I, Landry S, Malenfant E, Naud J, Ogilvie WW, O'Meara JA, Plante R, Simoneau B, Thavonekham B, Bös M, Cordingley MG. Yoakim C, et al. Among authors: naud j. Bioorg Med Chem Lett. 2004 Feb 9;14(3):739-42. doi: 10.1016/j.bmcl.2003.11.049. Bioorg Med Chem Lett. 2004. PMID: 14741280
Potent beta-lactam inhibitors of human cytomegalovirus protease.
Yoakim C, Ogilvie WW, Cameron DR, Chabot C, Grand-Maître C, Guse I, Haché B, Kawai S, Naud J, O'Meara JA, Plante R, Déziel R. Yoakim C, et al. Among authors: naud j. Antivir Chem Chemother. 1998 Sep;9(5):379-87. doi: 10.1177/095632029800900502. Antivir Chem Chemother. 1998. PMID: 9875391
89 results