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Mcl-1 and Bcl-xL regulate Bak/Bax-dependent apoptosis of the megakaryocytic lineage at multistages.
Kodama T, Hikita H, Kawaguchi T, Shigekawa M, Shimizu S, Hayashi Y, Li W, Miyagi T, Hosui A, Tatsumi T, Kanto T, Hiramatsu N, Kiyomizu K, Tadokoro S, Tomiyama Y, Hayashi N, Takehara T. Kodama T, et al. Among authors: li w. Cell Death Differ. 2012 Nov;19(11):1856-69. doi: 10.1038/cdd.2012.88. Epub 2012 Jul 13. Cell Death Differ. 2012. PMID: 22790873 Free PMC article.
Carbamazepine promotes liver regeneration and survival in mice.
Kawaguchi T, Kodama T, Hikita H, Tanaka S, Shigekawa M, Nawa T, Shimizu S, Li W, Miyagi T, Hiramatsu N, Tatsumi T, Takehara T. Kawaguchi T, et al. Among authors: li w. J Hepatol. 2013 Dec;59(6):1239-45. doi: 10.1016/j.jhep.2013.07.018. Epub 2013 Jul 18. J Hepatol. 2013. PMID: 23872603
The Bcl-2 homology domain 3 (BH3)-only proteins Bim and bid are functionally active and restrained by anti-apoptotic Bcl-2 family proteins in healthy liver.
Kodama T, Hikita H, Kawaguchi T, Saito Y, Tanaka S, Shigekawa M, Shimizu S, Li W, Miyagi T, Kanto T, Hiramatsu N, Tatsumi T, Takehara T. Kodama T, et al. Among authors: li w. J Biol Chem. 2013 Oct 18;288(42):30009-30018. doi: 10.1074/jbc.M112.443093. Epub 2013 Aug 28. J Biol Chem. 2013. PMID: 23986435 Free PMC article.
BH3-only protein bid participates in the Bcl-2 network in healthy liver cells.
Hikita H, Takehara T, Kodama T, Shimizu S, Hosui A, Miyagi T, Tatsumi T, Ishida H, Ohkawa K, Li W, Kanto T, Hiramatsu N, Hennighausen L, Yin XM, Hayashi N. Hikita H, et al. Among authors: li w. Hepatology. 2009 Dec;50(6):1972-80. doi: 10.1002/hep.23207. Hepatology. 2009. PMID: 19839062 Free PMC article.
BH3-only activator proteins Bid and Bim are dispensable for Bak/Bax-dependent thrombocyte apoptosis induced by Bcl-xL deficiency: molecular requisites for the mitochondrial pathway to apoptosis in platelets.
Kodama T, Takehara T, Hikita H, Shimizu S, Shigekawa M, Li W, Miyagi T, Hosui A, Tatsumi T, Ishida H, Kanto T, Hiramatsu N, Yin XM, Hayashi N. Kodama T, et al. Among authors: li w. J Biol Chem. 2011 Apr 22;286(16):13905-13. doi: 10.1074/jbc.M110.195370. Epub 2011 Mar 2. J Biol Chem. 2011. PMID: 21367852 Free PMC article.
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