Xue F - Search Results

1

Potent, highly selective, and orally bioavailable gem-difluorinated monocationic inhibitors of neuronal nitric oxide synthase.

Xue F, Li H, Delker SL, Fang J, Martásek P, Roman LJ, Poulos TL, Silverman RB. Xue F, et al. J Am Chem Soc. 2010 Oct 13;132(40):14229-38. doi: 10.1021/ja106175q. J Am Chem Soc. 2010. PMID: 20843082 Free PMC article.

2

Analogues of 2-aminopyridine-based selective inhibitors of neuronal nitric oxide synthase with increased bioavailability.

Lawton GR, Ralay Ranaivo H, Chico LK, Ji H, Xue F, Martásek P, Roman LJ, Watterson DM, Silverman RB. Lawton GR, et al. Among authors: xue f. Bioorg Med Chem. 2009 Mar 15;17(6):2371-80. doi: 10.1016/j.bmc.2009.02.017. Epub 2009 Feb 14. Bioorg Med Chem. 2009. PMID: 19268602 Free PMC article.

3

L337H mutant of rat neuronal nitric oxide synthase resembles human neuronal nitric oxide synthase toward inhibitors.

Fang J, Ji H, Lawton GR, Xue F, Roman LJ, Silverman RB. Fang J, et al. Among authors: xue f. J Med Chem. 2009 Jul 23;52(14):4533-7. doi: 10.1021/jm900380j. J Med Chem. 2009. PMID: 19537690 Free PMC article.

4

Concise route to the chiral pyrrolidine core of selective inhibitors of neuronal nitric oxide.

Xue F, Gu W, Silverman RB. Xue F, et al. Org Lett. 2009 Nov 19;11(22):5194-7. doi: 10.1021/ol902109t. Org Lett. 2009. PMID: 19860389 Free PMC article.

5

Potent and selective neuronal nitric oxide synthase inhibitors with improved cellular permeability.

Xue F, Fang J, Lewis WW, Martásek P, Roman LJ, Silverman RB. Xue F, et al. Bioorg Med Chem Lett. 2010 Jan 15;20(2):554-7. doi: 10.1016/j.bmcl.2009.11.086. Epub 2009 Nov 22. Bioorg Med Chem Lett. 2010. PMID: 19963381 Free PMC article.

6

Unexpected binding modes of nitric oxide synthase inhibitors effective in the prevention of a cerebral palsy phenotype in an animal model.

Delker SL, Ji H, Li H, Jamal J, Fang J, Xue F, Silverman RB, Poulos TL. Delker SL, et al. Among authors: xue f. J Am Chem Soc. 2010 Apr 21;132(15):5437-42. doi: 10.1021/ja910228a. J Am Chem Soc. 2010. PMID: 20337441 Free PMC article.

7

An Alkoxide Anion Triggered tert-Butyloxycarbonyl Group Migration. Mechanism and Application.

Xue F, Silverman RB. Xue F, et al. Tetrahedron Lett. 2010 May 5;51(18):2536-2538. doi: 10.1016/j.tetlet.2010.03.009. Tetrahedron Lett. 2010. PMID: 20414457 Free PMC article.

8

Structure-based design, synthesis, and biological evaluation of lipophilic-tailed monocationic inhibitors of neuronal nitric oxide synthase.

Xue F, Huang J, Ji H, Fang J, Li H, Martásek P, Roman LJ, Poulos TL, Silverman RB. Xue F, et al. Bioorg Med Chem. 2010 Sep 1;18(17):6526-37. doi: 10.1016/j.bmc.2010.06.074. Epub 2010 Jul 1. Bioorg Med Chem. 2010. PMID: 20673724 Free PMC article.

9

Peripheral but crucial: a hydrophobic pocket (Tyr(706), Leu(337), and Met(336)) for potent and selective inhibition of neuronal nitric oxide synthase.

Xue F, Li H, Fang J, Roman LJ, Martásek P, Poulos TL, Silverman RB. Xue F, et al. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6258-61. doi: 10.1016/j.bmcl.2010.08.096. Epub 2010 Aug 26. Bioorg Med Chem Lett. 2010. PMID: 20833542 Free PMC article.

10

Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase.

Delker SL, Xue F, Li H, Jamal J, Silverman RB, Poulos TL. Delker SL, et al. Among authors: xue f. Biochemistry. 2010 Dec 28;49(51):10803-10. doi: 10.1021/bi1013479. Epub 2010 Dec 7. Biochemistry. 2010. PMID: 21138269 Free PMC article.

This prompted us to design and synthesize symmetric "double-headed" inhibitors with an aminopyridine at each end of a bridging ring structure [Xue, F., Delker, S. L., Li, H., Fang, J., Jamal, J., Martasek, P., Roman, L. ...

This prompted us to design and synthesize symmetric "double-headed" inhibitors with an aminopyridine at each end of a bridging ring structur …

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