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Aziridine-2,3-dicarboxylate-based cysteine cathepsin inhibitors induce cell death in Leishmania major associated with accumulation of debris in autophagy-related lysosome-like vacuoles.
Antimicrob Agents Chemother. 2010 Dec;54(12):5028-41. doi: 10.1128/AAC.00327-10. Epub 2010 Sep 20.
Antimicrob Agents Chemother. 2010.
PMID: 20855728
Free PMC article.
A novel Leishmania major amastigote assay in 96-well format for rapid drug screening and its use for discovery and evaluation of a new class of leishmanicidal quinolinium salts.
Bringmann G, Thomale K, Bischof S, Schneider C, Schultheis M, Schwarz T, Moll H, Schurigt U.
Bringmann G, et al. Among authors: thomale k.
Antimicrob Agents Chemother. 2013 Jul;57(7):3003-11. doi: 10.1128/AAC.02201-12. Epub 2013 Apr 15.
Antimicrob Agents Chemother. 2013.
PMID: 23587955
Free PMC article.
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Valeriana wallichii root extracts and fractions with activity against Leishmania spp.
Ghosh S, Debnath S, Hazra S, Hartung A, Thomale K, Schultheis M, Kapkova P, Schurigt U, Moll H, Holzgrabe U, Hazra B.
Ghosh S, et al. Among authors: thomale k.
Parasitol Res. 2011 Apr;108(4):861-71. doi: 10.1007/s00436-010-2127-0. Epub 2010 Nov 18.
Parasitol Res. 2011.
PMID: 21085992
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