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Safety, tolerability, pharmacokinetics and pharmacodynamics of the oral cyclin-dependent kinase inhibitor AZD5438 when administered at intermittent and continuous dosing schedules in patients with advanced solid tumours.
Boss DS, Schwartz GK, Middleton MR, Amakye DD, Swaisland H, Midgley RS, Ranson M, Danson S, Calvert H, Plummer R, Morris C, Carvajal RD, Chirieac LR, Schellens JHM, Shapiro GI. Boss DS, et al. Ann Oncol. 2010 Apr;21(4):884-894. doi: 10.1093/annonc/mdp377. Epub 2009 Oct 13. Ann Oncol. 2010. PMID: 19825886 Free PMC article. Clinical Trial.
Phase I dose-escalation study of the pan-HER inhibitor, PF299804, in patients with advanced malignant solid tumors.
Jänne PA, Boss DS, Camidge DR, Britten CD, Engelman JA, Garon EB, Guo F, Wong S, Liang J, Letrent S, Millham R, Taylor I, Eckhardt SG, Schellens JH. Jänne PA, et al. Among authors: boss ds. Clin Cancer Res. 2011 Mar 1;17(5):1131-9. doi: 10.1158/1078-0432.CCR-10-1220. Epub 2011 Jan 10. Clin Cancer Res. 2011. PMID: 21220471 Free PMC article. Clinical Trial.
Phase I and pharmacological trial of lapatinib in combination with gemcitabine in patients with advanced breast cancer.
van der Noll R, Smit WM, Wymenga AN, Boss DS, Grob M, Huitema AD, Rosing H, Tibben MM, Keessen M, Rehorst H, Beijnen JH, Schellens JH. van der Noll R, et al. Among authors: boss ds. Invest New Drugs. 2015 Dec;33(6):1197-205. doi: 10.1007/s10637-015-0281-z. Epub 2015 Sep 11. Invest New Drugs. 2015. PMID: 26362459 Free PMC article. Clinical Trial.
Inducing synthetic lethality using PARP inhibitors.
Boss DS, Beijnen JH, Schellens JH. Boss DS, et al. Curr Clin Pharmacol. 2010 Aug;5(3):192-5. doi: 10.2174/157488410791498798. Curr Clin Pharmacol. 2010. PMID: 20406170 Review.
18 results