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In vitro evaluation of cytochrome P450 and glucuronidation activities in hepatocytes isolated from liver-humanized mice.
Yamasaki C, Kataoka M, Kato Y, Kakuni M, Usuda S, Ohzone Y, Matsuda S, Adachi Y, Ninomiya S, Itamoto T, Asahara T, Yoshizato K, Tateno C. Yamasaki C, et al. Among authors: ninomiya s. Drug Metab Pharmacokinet. 2010;25(6):539-50. doi: 10.2133/dmpk.dmpk-10-rg-047. Epub 2010 Oct 1. Drug Metab Pharmacokinet. 2010. PMID: 20930422 Free article.
Assessment of Protein Binding of 5-Hydroxythalidomide Bioactivated in Humanized Mice with Human P450 3A-Chromosome or Hepatocytes by Two-Dimensional Electrophoresis/Accelerator Mass Spectrometry.
Yamazaki H, Suemizu H, Kazuki Y, Oofusa K, Kuribayashi S, Shimizu M, Ninomiya S, Horie T, Shibata N, Guengerich FP. Yamazaki H, et al. Among authors: ninomiya s. Chem Res Toxicol. 2016 Aug 15;29(8):1279-81. doi: 10.1021/acs.chemrestox.6b00210. Epub 2016 Jul 29. Chem Res Toxicol. 2016. PMID: 27464947 Free PMC article.
Cytochrome P450 species involved in the metabolism of quinoline.
Reigh G, McMahon H, Ishizaki M, Ohara T, Shimane K, Esumi Y, Green C, Tyson C, Ninomiya S. Reigh G, et al. Among authors: ninomiya s. Carcinogenesis. 1996 Sep;17(9):1989-96. doi: 10.1093/carcin/17.9.1989. Carcinogenesis. 1996. PMID: 8824525
Simulation of human plasma concentration-time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite using humanized chimeric mice and semi-physiological pharmacokinetic modeling.
Kamimura H, Ito S, Chijiwa H, Okuzono T, Ishiguro T, Yamamoto Y, Nishinoaki S, Ninomiya SI, Mitsui M, Kalgutkar AS, Yamazaki H, Suemizu H. Kamimura H, et al. Among authors: ninomiya si. Xenobiotica. 2017 May;47(5):382-393. doi: 10.1080/00498254.2016.1199063. Epub 2016 Jul 7. Xenobiotica. 2017. PMID: 27389028
412 results