Moreira R - Search Results

1

Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: toward combination chemotherapy of malaria through a single chemical entity.

Gibbons P, Verissimo E, Araujo NC, Barton V, Nixon GL, Amewu RK, Chadwick J, Stocks PA, Biagini GA, Srivastava A, Rosenthal PJ, Gut J, Guedes RC, Moreira R, Sharma R, Berry N, Cristiano ML, Shone AE, Ward SA, O'Neill PM. Gibbons P, et al. Among authors: moreira r. J Med Chem. 2010 Nov 25;53(22):8202-6. doi: 10.1021/jm1009567. Epub 2010 Oct 27. J Med Chem. 2010. PMID: 20979352

2

An endoperoxide-based hybrid approach to deliver falcipain inhibitors inside malaria parasites.

Oliveira R, Newton AS, Guedes RC, Miranda D, Amewu RK, Srivastava A, Gut J, Rosenthal PJ, O'Neill PM, Ward SA, Lopes F, Moreira R. Oliveira R, et al. Among authors: moreira r. ChemMedChem. 2013 Sep;8(9):1528-36. doi: 10.1002/cmdc.201300202. Epub 2013 Jul 12. ChemMedChem. 2013. PMID: 23853126

3

The Bsmoc group as a novel scaffold for the design of irreversible inhibitors of cysteine proteases.

Iley J, Moreira R, Martins L, Guedes RC, Soares CM. Iley J, et al. Among authors: moreira r. Bioorg Med Chem Lett. 2006 May 15;16(10):2738-41. doi: 10.1016/j.bmcl.2006.02.007. Epub 2006 Feb 28. Bioorg Med Chem Lett. 2006. PMID: 16503139

4

Dipeptide vinyl sultams: synthesis via the Wittig-Horner reaction and activity against papain, falcipain-2 and Plasmodium falciparum.

Valente C, Guedes RC, Moreira R, Iley J, Gut J, Rosenthal PJ. Valente C, et al. Among authors: moreira r. Bioorg Med Chem Lett. 2006 Aug 1;16(15):4115-9. doi: 10.1016/j.bmcl.2006.04.079. Epub 2006 May 12. Bioorg Med Chem Lett. 2006. PMID: 16697641

5

Cryptolepine analogues containing basic aminoalkyl side-chains at C-11: synthesis, antiplasmodial activity, and cytotoxicity.

Lavrado J, Paulo A, Gut J, Rosenthal PJ, Moreira R. Lavrado J, et al. Among authors: moreira r. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1378-81. doi: 10.1016/j.bmcl.2008.01.015. Epub 2008 Jan 9. Bioorg Med Chem Lett. 2008. PMID: 18207399

6

Artemisinin-dipeptidyl vinyl sulfone hybrid molecules: design, synthesis and preliminary SAR for antiplasmodial activity and falcipain-2 inhibition.

Capela R, Oliveira R, Gonçalves LM, Domingos A, Gut J, Rosenthal PJ, Lopes F, Moreira R. Capela R, et al. Among authors: moreira r. Bioorg Med Chem Lett. 2009 Jun 15;19(12):3229-32. doi: 10.1016/j.bmcl.2009.04.100. Epub 2009 May 3. Bioorg Med Chem Lett. 2009. PMID: 19435664 Free PMC article.

7

Design, synthesis and structure-activity relationships of (1H-pyridin-4-ylidene)amines as potential antimalarials.

Rodrigues T, Guedes RC, dos Santos DJ, Carrasco M, Gut J, Rosenthal PJ, Moreira R, Lopes F. Rodrigues T, et al. Among authors: moreira r. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3476-80. doi: 10.1016/j.bmcl.2009.05.017. Epub 2009 May 9. Bioorg Med Chem Lett. 2009. PMID: 19467600

8

Synthesis and evaluation of vinyl sulfones as caspase-3 inhibitors. A structure-activity study.

Newton AS, Glória PM, Gonçalves LM, dos Santos DJ, Moreira R, Guedes RC, Santos MM. Newton AS, et al. Among authors: moreira r. Eur J Med Chem. 2010 Sep;45(9):3858-63. doi: 10.1016/j.ejmech.2010.05.039. Epub 2010 May 24. Eur J Med Chem. 2010. PMID: 20541849

9

Incorporation of basic side chains into cryptolepine scaffold: structure-antimalarial activity relationships and mechanistic studies.

Lavrado J, Cabal GG, Prudêncio M, Mota MM, Gut J, Rosenthal PJ, Díaz C, Guedes RC, dos Santos DJ, Bichenkova E, Douglas KT, Moreira R, Paulo A. Lavrado J, et al. Among authors: moreira r. J Med Chem. 2011 Feb 10;54(3):734-50. doi: 10.1021/jm101383f. Epub 2011 Jan 5. J Med Chem. 2011. PMID: 21207937

10

Design, synthesis and evaluation of 3-methylene-substituted indolinones as antimalarials.

Praveen Kumar S, Gut J, Guedes RC, Rosenthal PJ, Santos MM, Moreira R. Praveen Kumar S, et al. Among authors: moreira r. Eur J Med Chem. 2011 Mar;46(3):927-33. doi: 10.1016/j.ejmech.2011.01.008. Epub 2011 Jan 15. Eur J Med Chem. 2011. PMID: 21295887

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