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Naturally occurring genetic variants in human chromogranin A (CHGA) associated with hypertension as well as hypertensive renal disease.
Chen Y, Rao F, Wen G, Gayen JR, Zhang K, Vaingankar SM, Biswas N, Mahata M, Friese RS, Fung MM, Salem RM, Nievergelt C, Bhatnagar V, Hook VY, Ziegler MG, Mahata SK, Hamilton BA, O'Connor DT. Chen Y, et al. Among authors: zhang k. Cell Mol Neurobiol. 2010 Nov;30(8):1395-400. doi: 10.1007/s10571-010-9600-2. Cell Mol Neurobiol. 2010. PMID: 21061160 Free PMC article.
Discovery of common human genetic variants of GTP cyclohydrolase 1 (GCH1) governing nitric oxide, autonomic activity, and cardiovascular risk.
Zhang L, Rao F, Zhang K, Khandrika S, Das M, Vaingankar SM, Bao X, Rana BK, Smith DW, Wessel J, Salem RM, Rodriguez-Flores JL, Mahata SK, Schork NJ, Ziegler MG, O'Connor DT. Zhang L, et al. Among authors: zhang k. J Clin Invest. 2007 Sep;117(9):2658-71. doi: 10.1172/JCI31093. J Clin Invest. 2007. PMID: 17717598 Free PMC article.
Chromogranin A regulates renal function by triggering Weibel-Palade body exocytosis.
Chen Y, Mahata M, Rao F, Khandrika S, Courel M, Fung MM, Zhang K, Stridsberg M, Ziegler MG, Hamilton BA, Lipkowitz MS, Taupenot L, Nievergelt C, Mahata SK, O'Connor DT. Chen Y, et al. Among authors: zhang k. J Am Soc Nephrol. 2009 Jul;20(7):1623-32. doi: 10.1681/ASN.2008111148. Epub 2009 Jun 11. J Am Soc Nephrol. 2009. PMID: 19520754 Free PMC article.
Neuropeptide Y(1) Receptor NPY1R discovery of naturally occurring human genetic variants governing gene expression in cella as well as pleiotropic effects on autonomic activity and blood pressure in vivo.
Wang L, Rao F, Zhang K, Mahata M, Rodriguez-Flores JL, Fung MM, Waalen J, Cockburn MG, Hamilton BA, Mahata SK, O'Connor DT. Wang L, et al. Among authors: zhang k. J Am Coll Cardiol. 2009 Sep 1;54(10):944-54. doi: 10.1016/j.jacc.2009.05.035. J Am Coll Cardiol. 2009. PMID: 19712806 Free PMC article.
Autonomic function in hypertension; role of genetic variation at the catecholamine storage vesicle protein chromogranin B.
Zhang K, Rao F, Rana BK, Gayen JR, Calegari F, King A, Rosa P, Huttner WB, Stridsberg M, Mahata M, Vaingankar S, Mahboubi V, Salem RM, Rodriguez-Flores JL, Fung MM, Smith DW, Schork NJ, Ziegler MG, Taupenot L, Mahata SK, O'Connor DT. Zhang K, et al. Circ Cardiovasc Genet. 2009 Feb;2(1):46-56. doi: 10.1161/CIRCGENETICS.108.785659. Circ Cardiovasc Genet. 2009. PMID: 20011129 Free PMC article.
Role of reactive oxygen species in hyperadrenergic hypertension: biochemical, physiological, and pharmacological evidence from targeted ablation of the chromogranin a (Chga) gene.
Gayen JR, Zhang K, RamachandraRao SP, Mahata M, Chen Y, Kim HS, Naviaux RK, Sharma K, Mahata SK, O'Connor DT. Gayen JR, et al. Among authors: zhang k. Circ Cardiovasc Genet. 2010 Oct;3(5):414-25. doi: 10.1161/CIRCGENETICS.109.924050. Epub 2010 Aug 20. Circ Cardiovasc Genet. 2010. PMID: 20729505 Free PMC article.
MicroRNA-22 and promoter motif polymorphisms at the Chga locus in genetic hypertension: functional and therapeutic implications for gene expression and the pathogenesis of hypertension.
Friese RS, Altshuler AE, Zhang K, Miramontes-Gonzalez JP, Hightower CM, Jirout ML, Salem RM, Gayen JR, Mahapatra NR, Biswas N, Cale M, Vaingankar SM, Kim HS, Courel M, Taupenot L, Ziegler MG, Schork NJ, Pravenec M, Mahata SK, Schmid-Schönbein GW, O'Connor DT. Friese RS, et al. Among authors: zhang k. Hum Mol Genet. 2013 Sep 15;22(18):3624-40. doi: 10.1093/hmg/ddt213. Epub 2013 May 13. Hum Mol Genet. 2013. PMID: 23674521 Free PMC article.
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