Brüning JC - Search Results

1

Overexpression of Fto leads to increased food intake and results in obesity.

Church C, Moir L, McMurray F, Girard C, Banks GT, Teboul L, Wells S, Brüning JC, Nolan PM, Ashcroft FM, Cox RD. Church C, et al. Among authors: bruning jc. Nat Genet. 2010 Dec;42(12):1086-92. doi: 10.1038/ng.713. Epub 2010 Nov 14. Nat Genet. 2010. PMID: 21076408 Free PMC article.

2

Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity.

Plum L, Ma X, Hampel B, Balthasar N, Coppari R, Münzberg H, Shanabrough M, Burdakov D, Rother E, Janoschek R, Alber J, Belgardt BF, Koch L, Seibler J, Schwenk F, Fekete C, Suzuki A, Mak TW, Krone W, Horvath TL, Ashcroft FM, Brüning JC. Plum L, et al. Among authors: bruning jc. J Clin Invest. 2006 Jul;116(7):1886-901. doi: 10.1172/JCI27123. Epub 2006 Jun 22. J Clin Invest. 2006. PMID: 16794735 Free PMC article.

3

Electrical inhibition of identified anorexigenic POMC neurons by orexin/hypocretin.

Ma X, Zubcevic L, Brüning JC, Ashcroft FM, Burdakov D. Ma X, et al. Among authors: bruning jc. J Neurosci. 2007 Feb 14;27(7):1529-33. doi: 10.1523/JNEUROSCI.3583-06.2007. J Neurosci. 2007. PMID: 17301161 Free PMC article.

4

Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production.

Könner AC, Janoschek R, Plum L, Jordan SD, Rother E, Ma X, Xu C, Enriori P, Hampel B, Barsh GS, Kahn CR, Cowley MA, Ashcroft FM, Brüning JC. Könner AC, et al. Among authors: bruning jc. Cell Metab. 2007 Jun;5(6):438-49. doi: 10.1016/j.cmet.2007.05.004. Cell Metab. 2007. PMID: 17550779 Free article.

5

Glucagon-like peptide 1 stimulates hypothalamic proopiomelanocortin neurons.

Ma X, Bruning J, Ashcroft FM. Ma X, et al. J Neurosci. 2007 Jul 4;27(27):7125-9. doi: 10.1523/JNEUROSCI.1025-07.2007. J Neurosci. 2007. Retraction in: J Neurosci. 2011 Jun 8;31(23):8698.. PMID: 17611265 Free PMC article. Retracted.

6

Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes.

Girard CA, Wunderlich FT, Shimomura K, Collins S, Kaizik S, Proks P, Abdulkader F, Clark A, Ball V, Zubcevic L, Bentley L, Clark R, Church C, Hugill A, Galvanovskis J, Cox R, Rorsman P, Brüning JC, Ashcroft FM. Girard CA, et al. Among authors: bruning jc. J Clin Invest. 2009 Jan;119(1):80-90. doi: 10.1172/JCI35772. Epub 2008 Dec 8. J Clin Invest. 2009. PMID: 19065048 Free PMC article.

7

Inactivation of the Fto gene protects from obesity.

Fischer J, Koch L, Emmerling C, Vierkotten J, Peters T, Brüning JC, Rüther U. Fischer J, et al. Among authors: bruning jc. Nature. 2009 Apr 16;458(7240):894-8. doi: 10.1038/nature07848. Epub 2009 Feb 22. Nature. 2009. PMID: 19234441

8

Myeloid cell-restricted insulin receptor deficiency protects against obesity-induced inflammation and systemic insulin resistance.

Mauer J, Chaurasia B, Plum L, Quast T, Hampel B, Blüher M, Kolanus W, Kahn CR, Brüning JC. Mauer J, et al. Among authors: bruning jc. PLoS Genet. 2010 May 6;6(5):e1000938. doi: 10.1371/journal.pgen.1000938. PLoS Genet. 2010. PMID: 20463885 Free PMC article.

9

Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism.

Jordan SD, Krüger M, Willmes DM, Redemann N, Wunderlich FT, Brönneke HS, Merkwirth C, Kashkar H, Olkkonen VM, Böttger T, Braun T, Seibler J, Brüning JC. Jordan SD, et al. Among authors: bruning jc. Nat Cell Biol. 2011 Apr;13(4):434-46. doi: 10.1038/ncb2211. Epub 2011 Mar 27. Nat Cell Biol. 2011. PMID: 21441927

10

High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons.

Klöckener T, Hess S, Belgardt BF, Paeger L, Verhagen LA, Husch A, Sohn JW, Hampel B, Dhillon H, Zigman JM, Lowell BB, Williams KW, Elmquist JK, Horvath TL, Kloppenburg P, Brüning JC. Klöckener T, et al. Among authors: bruning jc. Nat Neurosci. 2011 Jun 5;14(7):911-8. doi: 10.1038/nn.2847. Nat Neurosci. 2011. PMID: 21642975 Free PMC article.

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