Chen Y - Search Results

1

An Ash2L/RbBP5 heterodimer stimulates the MLL1 methyltransferase activity through coordinated substrate interactions with the MLL1 SET domain.

Cao F, Chen Y, Cierpicki T, Liu Y, Basrur V, Lei M, Dou Y. Cao F, et al. Among authors: chen y. PLoS One. 2010 Nov 23;5(11):e14102. doi: 10.1371/journal.pone.0014102. PLoS One. 2010. PMID: 21124902 Free PMC article.

2

Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding.

Chen Y, Wan B, Wang KC, Cao F, Yang Y, Protacio A, Dou Y, Chang HY, Lei M. Chen Y, et al. EMBO Rep. 2011 Jun 10;12(8):797-803. doi: 10.1038/embor.2011.101. EMBO Rep. 2011. PMID: 21660059 Free PMC article.

3

High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction.

Karatas H, Townsend EC, Cao F, Chen Y, Bernard D, Liu L, Lei M, Dou Y, Wang S. Karatas H, et al. Among authors: chen y. J Am Chem Soc. 2013 Jan 16;135(2):669-82. doi: 10.1021/ja306028q. Epub 2012 Dec 27. J Am Chem Soc. 2013. PMID: 23210835 Free PMC article.

4

Targeting MLL1 H3K4 methyltransferase activity in mixed-lineage leukemia.

Cao F, Townsend EC, Karatas H, Xu J, Li L, Lee S, Liu L, Chen Y, Ouillette P, Zhu J, Hess JL, Atadja P, Lei M, Qin ZS, Malek S, Wang S, Dou Y. Cao F, et al. Among authors: chen y. Mol Cell. 2014 Jan 23;53(2):247-61. doi: 10.1016/j.molcel.2013.12.001. Epub 2014 Jan 2. Mol Cell. 2014. PMID: 24389101 Free PMC article.

5

Structural basis for activity regulation of MLL family methyltransferases.

Li Y, Han J, Zhang Y, Cao F, Liu Z, Li S, Wu J, Hu C, Wang Y, Shuai J, Chen J, Cao L, Li D, Shi P, Tian C, Zhang J, Dou Y, Li G, Chen Y, Lei M. Li Y, et al. Among authors: chen j, chen y. Nature. 2016 Feb 25;530(7591):447-52. doi: 10.1038/nature16952. Epub 2016 Feb 17. Nature. 2016. PMID: 26886794 Free PMC article.

6

Structure of the SPRY domain of human Ash2L and its interactions with RbBP5 and DPY30.

Chen Y, Cao F, Wan B, Dou Y, Lei M. Chen Y, et al. Cell Res. 2012 Mar;22(3):598-602. doi: 10.1038/cr.2012.9. Epub 2012 Jan 10. Cell Res. 2012. PMID: 22231628 Free PMC article. No abstract available.

7

Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction.

Karatas H, Li Y, Liu L, Ji J, Lee S, Chen Y, Yang J, Huang L, Bernard D, Xu J, Townsend EC, Cao F, Ran X, Li X, Wen B, Sun D, Stuckey JA, Lei M, Dou Y, Wang S. Karatas H, et al. Among authors: chen y. J Med Chem. 2017 Jun 22;60(12):4818-4839. doi: 10.1021/acs.jmedchem.6b01796. Epub 2017 Jun 12. J Med Chem. 2017. PMID: 28603984

8

Crystal structure of human histone lysine-specific demethylase 1 (LSD1).

Chen Y, Yang Y, Wang F, Wan K, Yamane K, Zhang Y, Lei M. Chen Y, et al. Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):13956-61. doi: 10.1073/pnas.0606381103. Epub 2006 Sep 6. Proc Natl Acad Sci U S A. 2006. PMID: 16956976 Free PMC article.

9

A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.

Chen Y, Yang Y, van Overbeek M, Donigian JR, Baciu P, de Lange T, Lei M. Chen Y, et al. Science. 2008 Feb 22;319(5866):1092-6. doi: 10.1126/science.1151804. Epub 2008 Jan 17. Science. 2008. PMID: 18202258

10

Structural basis of selective ubiquitination of TRF1 by SCFFbx4.

Zeng Z, Wang W, Yang Y, Chen Y, Yang X, Diehl JA, Liu X, Lei M. Zeng Z, et al. Among authors: chen y. Dev Cell. 2010 Feb 16;18(2):214-25. doi: 10.1016/j.devcel.2010.01.007. Dev Cell. 2010. PMID: 20159592 Free PMC article.

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