Song JS - Search Results

1

Discovery of novel N-β-D-xylosylindole derivatives as sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the management of hyperglycemia in diabetes.

Yao CH, Song JS, Chen CT, Yeh TK, Hung MS, Chang CC, Liu YW, Yuan MC, Hsieh CJ, Huang CY, Wang MH, Chiu CH, Hsieh TC, Wu SH, Hsiao WC, Chu KF, Tsai CH, Chao YS, Lee JC. Yao CH, et al. Among authors: song js. J Med Chem. 2011 Jan 13;54(1):166-78. doi: 10.1021/jm101072y. Epub 2010 Dec 3. J Med Chem. 2011. PMID: 21128592

2

Design, synthesis, and biological evaluation of novel alkenylthiophenes as potent and selective CB1 cannabinoid receptor antagonists.

Tai CL, Hung MS, Pawar VD, Tseng SL, Song JS, Hsieh WP, Chiu HH, Wu HC, Hsieh MT, Kuo CW, Hsieh CC, Tsao JP, Chao YS, Shia KS. Tai CL, et al. Among authors: song js. Org Biomol Chem. 2008 Feb 7;6(3):447-50. doi: 10.1039/b716434c. Epub 2007 Dec 10. Org Biomol Chem. 2008. PMID: 18219411

3

A cell-based high-throughput screen for epidermal growth factor receptor pathway inhibitors.

Lin WH, Song JS, Chang TY, Chang CY, Fu YN, Yeh CL, Wu SH, Huang YW, Fang MY, Lien TW, Hsieh HP, Chao YS, Huang SF, Tsai SF, Wang LM, Hsu JT, Chen YR. Lin WH, et al. Among authors: song js. Anal Biochem. 2008 Jun 1;377(1):89-94. doi: 10.1016/j.ab.2008.02.027. Epub 2008 Mar 4. Anal Biochem. 2008. PMID: 18358823

4

Bioisosteric replacement of the pyrazole 5-aryl moiety of N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A). A novel series of alkynylthiophenes as potent and selective cannabinoid-1 receptor antagonists.

Tseng SL, Hung MS, Chang CP, Song JS, Tai CL, Chiu HH, Hsieh WP, Lin Y, Chung WL, Kuo CW, Wu CH, Chu CM, Tung YS, Chao YS, Shia KS. Tseng SL, et al. Among authors: song js. J Med Chem. 2008 Sep 11;51(17):5397-412. doi: 10.1021/jm800066v. Epub 2008 Aug 20. J Med Chem. 2008. PMID: 18712856

5

Bioisosteric replacement of the pyrazole 3-carboxamide moiety of rimonabant. A novel series of oxadiazoles as CB1 cannabinoid receptor antagonists.

Chu CM, Hung MS, Hsieh MT, Kuo CW, Suja TD, Song JS, Chiu HH, Chao YS, Shia KS. Chu CM, et al. Among authors: song js. Org Biomol Chem. 2008 Sep 21;6(18):3399-407. doi: 10.1039/b807648k. Epub 2008 Jul 23. Org Biomol Chem. 2008. PMID: 18802648

6

Generation of ligand-based pharmacophore model and virtual screening for identification of novel tubulin inhibitors with potent anticancer activity.

Chiang YK, Kuo CC, Wu YS, Chen CT, Coumar MS, Wu JS, Hsieh HP, Chang CY, Jseng HY, Wu MH, Leou JS, Song JS, Chang JY, Lyu PC, Chao YS, Wu SY. Chiang YK, et al. Among authors: song js. J Med Chem. 2009 Jul 23;52(14):4221-33. doi: 10.1021/jm801649y. J Med Chem. 2009. PMID: 19507860

7

Discovery of 2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an active metabolite. A novel, potent and selective cannabinoid-1 receptor inverse agonist with high antiobesity efficacy in DIO mice.

Wu CH, Hung MS, Song JS, Yeh TK, Chou MC, Chu CM, Jan JJ, Hsieh MT, Tseng SL, Chang CP, Hsieh WP, Lin Y, Yeh YN, Chung WL, Kuo CW, Lin CY, Shy HS, Chao YS, Shia KS. Wu CH, et al. Among authors: song js. J Med Chem. 2009 Jul 23;52(14):4496-510. doi: 10.1021/jm900471u. J Med Chem. 2009. PMID: 19530697

8

Synthesis and biological activities of 2-amino-1-arylidenamino imidazoles as orally active anticancer agents.

Li WT, Hwang DR, Song JS, Chen CP, Chuu JJ, Hu CB, Lin HL, Huang CL, Huang CY, Tseng HY, Lin CC, Chen TW, Lin CH, Wang HS, Shen CC, Chang CM, Chao YS, Chen CT. Li WT, et al. Among authors: song js. J Med Chem. 2010 Mar 25;53(6):2409-17. doi: 10.1021/jm901501s. J Med Chem. 2010. PMID: 20170097

9

(2S,4S)-1-[2-(1,1-dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV.

Yeh TK, Tsai TY, Hsu T, Cheng JH, Chen X, Song JS, Shy HS, Chiou MC, Chien CH, Tseng YJ, Huang CY, Yeh KC, Huang YL, Huang CH, Huang YW, Wang MH, Tang HK, Chao YS, Chen CT, Jiaang WT. Yeh TK, et al. Among authors: song js. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3596-600. doi: 10.1016/j.bmcl.2010.04.124. Epub 2010 May 17. Bioorg Med Chem Lett. 2010. PMID: 20483603

10

Fast-forwarding hit to lead: aurora and epidermal growth factor receptor kinase inhibitor lead identification.

Coumar MS, Chu CY, Lin CW, Shiao HY, Ho YL, Reddy R, Lin WH, Chen CH, Peng YH, Leou JS, Lien TW, Huang CT, Fang MY, Wu SH, Wu JS, Chittimalla SK, Song JS, Hsu JT, Wu SY, Liao CC, Chao YS, Hsieh HP. Coumar MS, et al. Among authors: song js. J Med Chem. 2010 Jul 8;53(13):4980-8. doi: 10.1021/jm1000198. J Med Chem. 2010. PMID: 20550212

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