Engh RA - Search Results

1

Phthalazinone pyrazoles as potent, selective, and orally bioavailable inhibitors of Aurora-A kinase.

Prime ME, Courtney SM, Brookfield FA, Marston RW, Walker V, Warne J, Boyd AE, Kairies NA, von der Saal W, Limberg A, Georges G, Engh RA, Goller B, Rueger P, Rueth M. Prime ME, et al. Among authors: engh ra. J Med Chem. 2011 Jan 13;54(1):312-9. doi: 10.1021/jm101346r. Epub 2010 Dec 3. J Med Chem. 2011. PMID: 21128645

2

Tetrahydro-isoquinoline-based factor Xa inhibitors.

Kucznierz R, Grams F, Leinert H, Marzenell K, Engh RA, von der Saal W. Kucznierz R, et al. Among authors: engh ra. J Med Chem. 1998 Dec 3;41(25):4983-94. doi: 10.1021/jm9800402. J Med Chem. 1998. PMID: 9836616

3

Diarylsulfonamides as selective, non-peptidic thrombin inhibitors.

Weber IR, Neidlein R, von der Saal W, Grams F, Leinert H, Strein K, Engh RA, Kucznierz R. Weber IR, et al. Among authors: engh ra. Bioorg Med Chem Lett. 1998 Jul 7;8(13):1613-8. doi: 10.1016/s0960-894x(98)00269-8. Bioorg Med Chem Lett. 1998. PMID: 9873400

4

Design and crystal structures of protein kinase B-selective inhibitors in complex with protein kinase A and mutants.

Breitenlechner CB, Friebe WG, Brunet E, Werner G, Graul K, Thomas U, Künkele KP, Schäfer W, Gassel M, Bossemeyer D, Huber R, Engh RA, Masjost B. Breitenlechner CB, et al. Among authors: engh ra. J Med Chem. 2005 Jan 13;48(1):163-70. doi: 10.1021/jm049701n. J Med Chem. 2005. PMID: 15634010

5

Luciferin and derivatives as a DYRK selective scaffold for the design of protein kinase inhibitors.

Rothweiler U, Eriksson J, Stensen W, Leeson F, Engh RA, Svendsen JS. Rothweiler U, et al. Among authors: engh ra. Eur J Med Chem. 2015 Apr 13;94:140-8. doi: 10.1016/j.ejmech.2015.02.035. Epub 2015 Feb 25. Eur J Med Chem. 2015. PMID: 25768698

6

Crystal structures of active SRC kinase domain complexes.

Breitenlechner CB, Kairies NA, Honold K, Scheiblich S, Koll H, Greiter E, Koch S, Schäfer W, Huber R, Engh RA. Breitenlechner CB, et al. Among authors: engh ra. J Mol Biol. 2005 Oct 21;353(2):222-31. doi: 10.1016/j.jmb.2005.08.023. J Mol Biol. 2005. PMID: 16168436

7

High thermostability and lack of cooperative DNA binding distinguish the p63 core domain from the homologous tumor suppressor p53.

Klein C, Georges G, Künkele KP, Huber R, Engh RA, Hansen S. Klein C, et al. Among authors: engh ra. J Biol Chem. 2001 Oct 5;276(40):37390-401. doi: 10.1074/jbc.M103801200. Epub 2001 Jul 26. J Biol Chem. 2001. PMID: 11477076 Free article.

8

Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors.

Czarna A, Wang J, Zelencova D, Liu Y, Deng X, Choi HG, Zhang T, Zhou W, Chang JW, Kildalsen H, Seternes OM, Gray NS, Engh RA, Rothweiler U. Czarna A, et al. Among authors: engh ra. J Med Chem. 2018 Sep 13;61(17):7560-7572. doi: 10.1021/acs.jmedchem.7b01847. Epub 2018 Aug 23. J Med Chem. 2018. PMID: 30095246

9

Probing the ATP-Binding Pocket of Protein Kinase DYRK1A with Benzothiazole Fragment Molecules.

Rothweiler U, Stensen W, Brandsdal BO, Isaksson J, Leeson FA, Engh RA, Svendsen JS. Rothweiler U, et al. Among authors: engh ra. J Med Chem. 2016 Nov 10;59(21):9814-9824. doi: 10.1021/acs.jmedchem.6b01086. Epub 2016 Oct 21. J Med Chem. 2016. PMID: 27736065

10

Structure-based optimization of novel azepane derivatives as PKB inhibitors.

Breitenlechner CB, Wegge T, Berillon L, Graul K, Marzenell K, Friebe WG, Thomas U, Schumacher R, Huber R, Engh RA, Masjost B. Breitenlechner CB, et al. Among authors: engh ra. J Med Chem. 2004 Mar 11;47(6):1375-90. doi: 10.1021/jm0310479. J Med Chem. 2004. PMID: 14998327

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