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The environmental pollutant and carcinogen 3-nitrobenzanthrone induces cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase in rat lung and kidney, thereby enhancing its own genotoxicity.
Stiborová M, Dracínská H, Mizerovská J, Frei E, Schmeiser HH, Hudecek J, Hodek P, Phillips DH, Arlt VM. Stiborová M, et al. Among authors: mizerovska j. Toxicology. 2008 May 2;247(1):11-22. doi: 10.1016/j.tox.2008.01.018. Epub 2008 Feb 6. Toxicology. 2008. PMID: 18329153
3-aminobenzanthrone, a human metabolite of the carcinogenic environmental pollutant 3-nitrobenzanthrone, induces biotransformation enzymes in rat kidney and lung.
Stiborová M, Dracínská H, Martínková M, Mizerovská J, Hudecek J, Hodek P, Liberda J, Frei E, Schmeiser HH, Phillips DH, Arlt VM. Stiborová M, et al. Among authors: mizerovska j. Mutat Res. 2009 May 31;676(1-2):93-101. doi: 10.1016/j.mrgentox.2009.04.013. Epub 2009 May 3. Mutat Res. 2009. PMID: 19398038