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Page 1
Structural basis of substrate discrimination and integrin binding by autotaxin.
Hausmann J, Kamtekar S, Christodoulou E, Day JE, Wu T, Fulkerson Z, Albers HM, van Meeteren LA, Houben AJ, van Zeijl L, Jansen S, Andries M, Hall T, Pegg LE, Benson TE, Kasiem M, Harlos K, Kooi CW, Smyth SS, Ovaa H, Bollen M, Morris AJ, Moolenaar WH, Perrakis A. Hausmann J, et al. Among authors: benson te. Nat Struct Mol Biol. 2011 Feb;18(2):198-204. doi: 10.1038/nsmb.1980. Epub 2011 Jan 16. Nat Struct Mol Biol. 2011. PMID: 21240271 Free PMC article.
Crystallization and preliminary X-ray diffraction analysis of rat autotaxin.
Day JE, Hall T, Pegg LE, Benson TE, Hausmann J, Kamtekar S. Day JE, et al. Among authors: benson te. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Sep 1;66(Pt 9):1127-9. doi: 10.1107/S1744309110030228. Epub 2010 Aug 31. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010. PMID: 20823544 Free PMC article.
Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6.
Chrencik JE, Patny A, Leung IK, Korniski B, Emmons TL, Hall T, Weinberg RA, Gormley JA, Williams JM, Day JE, Hirsch JL, Kiefer JR, Leone JW, Fischer HD, Sommers CD, Huang HC, Jacobsen EJ, Tenbrink RE, Tomasselli AG, Benson TE. Chrencik JE, et al. Among authors: benson te. J Mol Biol. 2010 Jul 16;400(3):413-33. doi: 10.1016/j.jmb.2010.05.020. Epub 2010 May 15. J Mol Biol. 2010. PMID: 20478313
Potent and selective isophthalamide S2 hydroxyethylamine inhibitors of BACE1.
Kortum SW, Benson TE, Bienkowski MJ, Emmons TL, Prince DB, Paddock DJ, Tomasselli AG, Moon JB, LaBorde A, TenBrink RE. Kortum SW, et al. Among authors: benson te. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3378-83. doi: 10.1016/j.bmcl.2007.03.096. Epub 2007 Apr 3. Bioorg Med Chem Lett. 2007. PMID: 17434734
Large-scale purification of human BACE expressed in mammalian cells and removal of the prosegment with HIV-1 protease to improve crystal diffraction.
Emmons TL, Shuck ME, Babcock MS, Holloway JS, Leone JW, Durbin JD, Paddock DJ, Prince DB, Heinrikson RL, Fischer HD, Bienkowski MJ, Benson TE, Tomasselli AG. Emmons TL, et al. Among authors: benson te. Protein Pept Lett. 2008;15(2):119-30. doi: 10.2174/092986608783489599. Protein Pept Lett. 2008. PMID: 18289104
Design of potent inhibitors of human beta-secretase. Part 1.
Freskos JN, Fobian YM, Benson TE, Bienkowski MJ, Brown DL, Emmons TL, Heintz R, Laborde A, McDonald JJ, Mischke BV, Molyneaux JM, Moon JB, Mullins PB, Bryan Prince D, Paddock DJ, Tomasselli AG, Winterrowd G. Freskos JN, et al. Among authors: benson te. Bioorg Med Chem Lett. 2007 Jan 1;17(1):73-7. doi: 10.1016/j.bmcl.2006.09.092. Epub 2006 Oct 4. Bioorg Med Chem Lett. 2007. PMID: 17046251
54 results