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Reversible competitive α-ketoheterocycle inhibitors of fatty acid amide hydrolase containing additional conformational constraints in the acyl side chain: orally active, long-acting analgesics.
Ezzili C, Mileni M, McGlinchey N, Long JZ, Kinsey SG, Hochstatter DG, Stevens RC, Lichtman AH, Cravatt BF, Bilsky EJ, Boger DL. Ezzili C, et al. Among authors: hochstatter dg. J Med Chem. 2011 Apr 28;54(8):2805-22. doi: 10.1021/jm101597x. Epub 2011 Mar 23. J Med Chem. 2011. PMID: 21428410 Free PMC article.
Optimization of alpha-ketooxazole inhibitors of fatty acid amide hydrolase.
Kimball FS, Romero FA, Ezzili C, Garfunkle J, Rayl TJ, Hochstatter DG, Hwang I, Boger DL. Kimball FS, et al. Among authors: hochstatter dg. J Med Chem. 2008 Feb 28;51(4):937-47. doi: 10.1021/jm701210y. Epub 2008 Feb 5. J Med Chem. 2008. PMID: 18247553 Free PMC article.