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Reversible competitive α-ketoheterocycle inhibitors of fatty acid amide hydrolase containing additional conformational constraints in the acyl side chain: orally active, long-acting analgesics.
J Med Chem. 2011 Apr 28;54(8):2805-22. doi: 10.1021/jm101597x. Epub 2011 Mar 23.
J Med Chem. 2011.
PMID: 21428410
Free PMC article.
Optimization of alpha-ketooxazole inhibitors of fatty acid amide hydrolase.
Kimball FS, Romero FA, Ezzili C, Garfunkle J, Rayl TJ, Hochstatter DG, Hwang I, Boger DL.
Kimball FS, et al. Among authors: hochstatter dg.
J Med Chem. 2008 Feb 28;51(4):937-47. doi: 10.1021/jm701210y. Epub 2008 Feb 5.
J Med Chem. 2008.
PMID: 18247553
Free PMC article.
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Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase.
Garfunkle J, Ezzili C, Rayl TJ, Hochstatter DG, Hwang I, Boger DL.
Garfunkle J, et al. Among authors: hochstatter dg.
J Med Chem. 2008 Aug 14;51(15):4392-403. doi: 10.1021/jm800136b. Epub 2008 Jul 16.
J Med Chem. 2008.
PMID: 18630870
Free PMC article.
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Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hydrolase.
DeMartino JK, Garfunkle J, Hochstatter DG, Cravatt BF, Boger DL.
DeMartino JK, et al. Among authors: hochstatter dg.
Bioorg Med Chem Lett. 2008 Nov 15;18(22):5842-6. doi: 10.1016/j.bmcl.2008.06.084. Epub 2008 Jun 28.
Bioorg Med Chem Lett. 2008.
PMID: 18639454
Free PMC article.
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Increasing the efficiency of the transannular Diels-Alder strategy via palladium(II)-catalyzed macrocyclizations.
Iafe RG, Kuo JL, Hochstatter DG, Saga T, Turner JW, Merlic CA.
Iafe RG, et al. Among authors: hochstatter dg.
Org Lett. 2013 Feb 1;15(3):582-5. doi: 10.1021/ol303394t. Epub 2013 Jan 23.
Org Lett. 2013.
PMID: 23343225
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