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Immunotoxins with decreased immunogenicity and improved activity.
Pastan I, Onda M, Weldon J, Fitzgerald D, Kreitman R. Pastan I, et al. Among authors: fitzgerald d. Leuk Lymphoma. 2011 Jun;52 Suppl 2(Suppl 2):87-90. doi: 10.3109/10428194.2011.573039. Epub 2011 Apr 19. Leuk Lymphoma. 2011. PMID: 21504287 Free PMC article.
Cell-mediated cleavage of Pseudomonas exotoxin between Arg279 and Gly280 generates the enzymatically active fragment which translocates to the cytosol.
Ogata M, Fryling CM, Pastan I, FitzGerald DJ. Ogata M, et al. Among authors: fitzgerald dj. J Biol Chem. 1992 Dec 15;267(35):25396-401. J Biol Chem. 1992. PMID: 1460035 Free article.
Pseudomonas exotoxin (PE) is a three-domain toxin which is cleaved by a cellular protease within cells and then reduced to generate two prominent fragments (Ogata, M., Chaudhary, V. K., Pastan, I., and FitzGerald, D. J. (1990) J. Biol. Chem. 265, 20678-20685). The N …
Pseudomonas exotoxin (PE) is a three-domain toxin which is cleaved by a cellular protease within cells and then reduced to generate two prom …
Recombinant toxins as novel therapeutic agents.
Pastan I, Chaudhary V, FitzGerald DJ. Pastan I, et al. Among authors: fitzgerald dj. Annu Rev Biochem. 1992;61:331-54. doi: 10.1146/annurev.bi.61.070192.001555. Annu Rev Biochem. 1992. PMID: 1497314 Review. No abstract available.
1,796 results