Distler AM - Search Results

1

Exploring the inhibition of CTX-M-9 by beta-lactamase inhibitors and carbapenems.

Bethel CR, Taracila M, Shyr T, Thomson JM, Distler AM, Hujer KM, Hujer AM, Endimiani A, Papp-Wallace K, Bonnet R, Bonomo RA. Bethel CR, et al. Among authors: distler am. Antimicrob Agents Chemother. 2011 Jul;55(7):3465-75. doi: 10.1128/AAC.00089-11. Epub 2011 May 9. Antimicrob Agents Chemother. 2011. PMID: 21555770 Free PMC article.

2

Inactivation of a class A and a class C β-lactamase by 6β-(hydroxymethyl)penicillanic acid sulfone.

Papp-Wallace KM, Bethel CR, Gootz TD, Shang W, Stroh J, Lau W, McLeod D, Price L, Marfat A, Distler A, Drawz SM, Chen H, Harry E, Nottingham M, Carey PR, Buynak JD, Bonomo RA. Papp-Wallace KM, et al. Biochem Pharmacol. 2012 Feb 15;83(4):462-71. doi: 10.1016/j.bcp.2011.11.015. Epub 2011 Dec 2. Biochem Pharmacol. 2012. PMID: 22155308 Free PMC article.

3

Overcoming resistance to beta-lactamase inhibitors: comparing sulbactam to novel inhibitors against clavulanate resistant SHV enzymes with substitutions at Ambler position 244.

Thomson JM, Distler AM, Bonomo RA. Thomson JM, et al. Among authors: distler am. Biochemistry. 2007 Oct 9;46(40):11361-8. doi: 10.1021/bi700792a. Epub 2007 Sep 12. Biochemistry. 2007. PMID: 17848099

4

Inhibition of OXA-1 beta-lactamase by penems.

Bethel CR, Distler AM, Ruszczycky MW, Carey MP, Carey PR, Hujer AM, Taracila M, Helfand MS, Thomson JM, Kalp M, Anderson VE, Leonard DA, Hujer KM, Abe T, Venkatesan AM, Mansour TS, Bonomo RA. Bethel CR, et al. Among authors: distler am. Antimicrob Agents Chemother. 2008 Sep;52(9):3135-43. doi: 10.1128/AAC.01677-07. Epub 2008 Jun 16. Antimicrob Agents Chemother. 2008. PMID: 18559643 Free PMC article.

5

Strategic design of an effective beta-lactamase inhibitor: LN-1-255, a 6-alkylidene-2'-substituted penicillin sulfone.

Pattanaik P, Bethel CR, Hujer AM, Hujer KM, Distler AM, Taracila M, Anderson VE, Fritsche TR, Jones RN, Pagadala SR, van den Akker F, Buynak JD, Bonomo RA. Pattanaik P, et al. Among authors: distler am. J Biol Chem. 2009 Jan 9;284(2):945-53. doi: 10.1074/jbc.M806833200. Epub 2008 Oct 27. J Biol Chem. 2009. PMID: 18955486 Free PMC article.

6

The role of a second-shell residue in modifying substrate and inhibitor interactions in the SHV beta-lactamase: a study of ambler position Asn276.

Drawz SM, Bethel CR, Hujer KM, Hurless KN, Distler AM, Caselli E, Prati F, Bonomo RA. Drawz SM, et al. Among authors: distler am. Biochemistry. 2009 Jun 2;48(21):4557-66. doi: 10.1021/bi9003292. Biochemistry. 2009. PMID: 19351161 Free PMC article.

7

Inhibition of the class C beta-lactamase from Acinetobacter spp.: insights into effective inhibitor design.

Drawz SM, Babic M, Bethel CR, Taracila M, Distler AM, Ori C, Caselli E, Prati F, Bonomo RA. Drawz SM, et al. Among authors: distler am. Biochemistry. 2010 Jan 19;49(2):329-40. doi: 10.1021/bi9015988. Biochemistry. 2010. PMID: 19925018 Free PMC article.

8

Inhibitor resistance in the KPC-2 beta-lactamase, a preeminent property of this class A beta-lactamase.

Papp-Wallace KM, Bethel CR, Distler AM, Kasuboski C, Taracila M, Bonomo RA. Papp-Wallace KM, et al. Among authors: distler am. Antimicrob Agents Chemother. 2010 Feb;54(2):890-7. doi: 10.1128/AAC.00693-09. Epub 2009 Dec 14. Antimicrob Agents Chemother. 2010. PMID: 20008772 Free PMC article.

9

Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase.

Papp-Wallace KM, Taracila M, Hornick JM, Hujer AM, Hujer KM, Distler AM, Endimiani A, Bonomo RA. Papp-Wallace KM, et al. Among authors: distler am. Antimicrob Agents Chemother. 2010 Jul;54(7):2867-77. doi: 10.1128/AAC.00197-10. Epub 2010 Apr 26. Antimicrob Agents Chemother. 2010. PMID: 20421396 Free PMC article.

10

Inhibition of class A beta-lactamases by carbapenems: crystallographic observation of two conformations of meropenem in SHV-1.

Nukaga M, Bethel CR, Thomson JM, Hujer AM, Distler A, Anderson VE, Knox JR, Bonomo RA. Nukaga M, et al. Among authors: distler a. J Am Chem Soc. 2008 Sep 24;130(38):12656-62. doi: 10.1021/ja7111146. Epub 2008 Aug 30. J Am Chem Soc. 2008. PMID: 18761444 Free PMC article.

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