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Selective inhibition of mitochondrial JNK signaling achieved using peptide mimicry of the Sab kinase interacting motif-1 (KIM1).
ACS Chem Biol. 2011 Aug 19;6(8):808-18. doi: 10.1021/cb200062a. Epub 2011 May 24.
ACS Chem Biol. 2011.
PMID: 21563797
Free PMC article.
Synthesis, biological evaluation, X-ray structure, and pharmacokinetics of aminopyrimidine c-jun-N-terminal kinase (JNK) inhibitors.
Kamenecka T, Jiang R, Song X, Duckett D, Chen W, Ling YY, Habel J, Laughlin JD, Chambers J, Figuera-Losada M, Cameron MD, Lin L, Ruiz CH, LoGrasso PV.
Kamenecka T, et al. Among authors: laughlin jd.
J Med Chem. 2010 Jan 14;53(1):419-31. doi: 10.1021/jm901351f.
J Med Chem. 2010.
PMID: 19947601
Free PMC article.
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Structural mechanisms of allostery and autoinhibition in JNK family kinases.
Laughlin JD, Nwachukwu JC, Figuera-Losada M, Cherry L, Nettles KW, LoGrasso PV.
Laughlin JD, et al.
Structure. 2012 Dec 5;20(12):2174-84. doi: 10.1016/j.str.2012.09.021. Epub 2012 Nov 8.
Structure. 2012.
PMID: 23142346
Free PMC article.
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Discovery of potent and selective covalent inhibitors of JNK.
Zhang T, Inesta-Vaquera F, Niepel M, Zhang J, Ficarro SB, Machleidt T, Xie T, Marto JA, Kim N, Sim T, Laughlin JD, Park H, LoGrasso PV, Patricelli M, Nomanbhoy TK, Sorger PK, Alessi DR, Gray NS.
Zhang T, et al. Among authors: laughlin jd.
Chem Biol. 2012 Jan 27;19(1):140-54. doi: 10.1016/j.chembiol.2011.11.010.
Chem Biol. 2012.
PMID: 22284361
Free PMC article.
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Activation of pheromone-sensitive neurons is mediated by conformational activation of pheromone-binding protein.
Laughlin JD, Ha TS, Jones DNM, Smith DP.
Laughlin JD, et al.
Cell. 2008 Jun 27;133(7):1255-1265. doi: 10.1016/j.cell.2008.04.046.
Cell. 2008.
PMID: 18585358
Free PMC article.
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Response of Lemna minor to Sodium Chloride and a Statistical Analysis of Continuous Measurements for EC50 and 95% Confidence Limits Calculation.
Buckley JA, Rustagi KP, Laughlin JD.
Buckley JA, et al. Among authors: laughlin jd.
Bull Environ Contam Toxicol. 1996 Dec;57(6):1003-8. doi: 10.1007/s001289900290.
Bull Environ Contam Toxicol. 1996.
PMID: 8875852
No abstract available.
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