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Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing.
Debdab M, Carreaux F, Renault S, Soundararajan M, Fedorov O, Filippakopoulos P, Lozach O, Babault L, Tahtouh T, Baratte B, Ogawa Y, Hagiwara M, Eisenreich A, Rauch U, Knapp S, Meijer L, Bazureau JP. Debdab M, et al. Among authors: soundararajan m. J Med Chem. 2011 Jun 23;54(12):4172-86. doi: 10.1021/jm200274d. Epub 2011 May 26. J Med Chem. 2011. PMID: 21615147
Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B.
Tahtouh T, Elkins JM, Filippakopoulos P, Soundararajan M, Burgy G, Durieu E, Cochet C, Schmid RS, Lo DC, Delhommel F, Oberholzer AE, Pearl LH, Carreaux F, Bazureau JP, Knapp S, Meijer L. Tahtouh T, et al. Among authors: soundararajan m. J Med Chem. 2012 Nov 8;55(21):9312-30. doi: 10.1021/jm301034u. Epub 2012 Oct 8. J Med Chem. 2012. PMID: 22998443
Novel Inverse Binding Mode of Indirubin Derivatives Yields Improved Selectivity for DYRK Kinases.
Myrianthopoulos V, Kritsanida M, Gaboriaud-Kolar N, Magiatis P, Ferandin Y, Durieu E, Lozach O, Cappel D, Soundararajan M, Filippakopoulos P, Sherman W, Knapp S, Meijer L, Mikros E, Skaltsounis AL. Myrianthopoulos V, et al. Among authors: soundararajan m. ACS Med Chem Lett. 2013 Jan 10;4(1):22-26. doi: 10.1021/ml300207a. Epub 2012 Nov 1. ACS Med Chem Lett. 2013. PMID: 23336033 Free PMC article.
UnPAKing the class differences among p21-activated kinases.
Eswaran J, Soundararajan M, Kumar R, Knapp S. Eswaran J, et al. Among authors: soundararajan m. Trends Biochem Sci. 2008 Aug;33(8):394-403. doi: 10.1016/j.tibs.2008.06.002. Epub 2008 Jul 17. Trends Biochem Sci. 2008. PMID: 18639460 Review.
Targeting group II PAKs in cancer and metastasis.
Eswaran J, Soundararajan M, Knapp S. Eswaran J, et al. Among authors: soundararajan m. Cancer Metastasis Rev. 2009 Jun;28(1-2):209-17. doi: 10.1007/s10555-008-9181-4. Cancer Metastasis Rev. 2009. PMID: 19160016 Review.
Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function.
Kwiatkowski N, Jelluma N, Filippakopoulos P, Soundararajan M, Manak MS, Kwon M, Choi HG, Sim T, Deveraux QL, Rottmann S, Pellman D, Shah JV, Kops GJ, Knapp S, Gray NS. Kwiatkowski N, et al. Among authors: soundararajan m. Nat Chem Biol. 2010 May;6(5):359-68. doi: 10.1038/nchembio.345. Epub 2010 Apr 11. Nat Chem Biol. 2010. PMID: 20383151 Free PMC article.
Resonance assignment of the RGS domain of human RGS10.
Fedorov OY, Higman VA, Schmieder P, Leidert M, Diehl A, Elkins J, Soundararajan M, Oschkinat H, Ball LJ. Fedorov OY, et al. Among authors: soundararajan m. J Biomol NMR. 2007 Jun;38(2):191. doi: 10.1007/s10858-006-9111-0. Epub 2006 Dec 19. J Biomol NMR. 2007. PMID: 17180548 No abstract available.
48 results