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Probing the biomechanical contribution of the endothelium to lymphocyte migration: diapedesis by the path of least resistance.
J Cell Sci. 2014 Sep 1;127(Pt 17):3720-34. doi: 10.1242/jcs.148619. Epub 2014 Jul 7.
J Cell Sci. 2014.
PMID: 25002404
Free PMC article.
Taken together, these data support the hypothesis that lymphocytes are guided by the mechanical 'path of least resistance' as they transverse the endothelium, a process we term 'tenertaxis'....
Taken together, these data support the hypothesis that lymphocytes are guided by the mechanical 'path of least resistance' as they transvers …
Antigen recognition is facilitated by invadosome-like protrusions formed by memory/effector T cells.
Sage PT, Varghese LM, Martinelli R, Sciuto TE, Kamei M, Dvorak AM, Springer TA, Sharpe AH, Carman CV.
Sage PT, et al. Among authors: sciuto te.
J Immunol. 2012 Apr 15;188(8):3686-99. doi: 10.4049/jimmunol.1102594. Epub 2012 Mar 21.
J Immunol. 2012.
PMID: 22442443
Free PMC article.
The resulting calcium flux stabilized dense arrays of ILPs (each enriched in TCR, protein kinase C-teta, ZAP70, phosphotyrosine, and HS1), forming what we term a podo-synapse. Similar findings were made using CD8 CTLs on endothelium. ...
The resulting calcium flux stabilized dense arrays of ILPs (each enriched in TCR, protein kinase C-teta, ZAP70, phosphotyrosine, and HS1), f …
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TM4SF1: a tetraspanin-like protein necessary for nanopodia formation and endothelial cell migration.
Zukauskas A, Merley A, Li D, Ang LH, Sciuto TE, Salman S, Dvorak AM, Dvorak HF, Jaminet SC.
Zukauskas A, et al. Among authors: sciuto te.
Angiogenesis. 2011 Sep;14(3):345-54. doi: 10.1007/s10456-011-9218-0. Epub 2011 May 29.
Angiogenesis. 2011.
PMID: 21626280
Free PMC article.
TM4SF1 is necessary for the formation of unusually long (up to a 50 mum), thin (~100-300 nm wide), F-actin-poor EC cell projections that we term 'nanopodia'. Immunostaining of nanopodia at both the light and electron microsopic levels localized TM4SF1 in a regularly spaced …
TM4SF1 is necessary for the formation of unusually long (up to a 50 mum), thin (~100-300 nm wide), F-actin-poor EC cell projections that we …
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