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Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in mice.
Kodama T, Takehara T, Hikita H, Shimizu S, Shigekawa M, Tsunematsu H, Li W, Miyagi T, Hosui A, Tatsumi T, Ishida H, Kanto T, Hiramatsu N, Kubota S, Takigawa M, Tomimaru Y, Tomokuni A, Nagano H, Doki Y, Mori M, Hayashi N. Kodama T, et al. Among authors: li w. J Clin Invest. 2011 Aug;121(8):3343-56. doi: 10.1172/JCI44957. Epub 2011 Jul 11. J Clin Invest. 2011. PMID: 21747166 Free PMC article.
Pancreatic STAT3 protects mice against caerulein-induced pancreatitis via PAP1 induction.
Shigekawa M, Hikita H, Kodama T, Shimizu S, Li W, Uemura A, Miyagi T, Hosui A, Kanto T, Hiramatsu N, Tatsumi T, Takeda K, Akira S, Takehara T. Shigekawa M, et al. Among authors: li w. Am J Pathol. 2012 Dec;181(6):2105-13. doi: 10.1016/j.ajpath.2012.08.038. Epub 2012 Oct 10. Am J Pathol. 2012. PMID: 23064197 Free article.
The Bcl-2 homology domain 3 (BH3)-only proteins Bim and bid are functionally active and restrained by anti-apoptotic Bcl-2 family proteins in healthy liver.
Kodama T, Hikita H, Kawaguchi T, Saito Y, Tanaka S, Shigekawa M, Shimizu S, Li W, Miyagi T, Kanto T, Hiramatsu N, Tatsumi T, Takehara T. Kodama T, et al. Among authors: li w. J Biol Chem. 2013 Oct 18;288(42):30009-30018. doi: 10.1074/jbc.M112.443093. Epub 2013 Aug 28. J Biol Chem. 2013. PMID: 23986435 Free PMC article.
Thrombocytopenia exacerbates cholestasis-induced liver fibrosis in mice.
Kodama T, Takehara T, Hikita H, Shimizu S, Li W, Miyagi T, Hosui A, Tatsumi T, Ishida H, Tadokoro S, Ido A, Tsubouchi H, Hayashi N. Kodama T, et al. Among authors: li w. Gastroenterology. 2010 Jun;138(7):2487-98, 2498.e1-7. doi: 10.1053/j.gastro.2010.02.054. Epub 2010 Mar 2. Gastroenterology. 2010. PMID: 20206174
Involvement of STAT3-regulated hepatic soluble factors in attenuation of stellate cell activity and liver fibrogenesis in mice.
Shigekawa M, Takehara T, Kodama T, Hikita H, Shimizu S, Li W, Miyagi T, Hosui A, Tatsumi T, Ishida H, Kanto T, Hiramatsu N, Hayashi N. Shigekawa M, et al. Among authors: li w. Biochem Biophys Res Commun. 2011 Mar 25;406(4):614-20. doi: 10.1016/j.bbrc.2011.02.105. Epub 2011 Feb 26. Biochem Biophys Res Commun. 2011. PMID: 21356197
Mcl-1 and Bcl-xL regulate Bak/Bax-dependent apoptosis of the megakaryocytic lineage at multistages.
Kodama T, Hikita H, Kawaguchi T, Shigekawa M, Shimizu S, Hayashi Y, Li W, Miyagi T, Hosui A, Tatsumi T, Kanto T, Hiramatsu N, Kiyomizu K, Tadokoro S, Tomiyama Y, Hayashi N, Takehara T. Kodama T, et al. Among authors: li w. Cell Death Differ. 2012 Nov;19(11):1856-69. doi: 10.1038/cdd.2012.88. Epub 2012 Jul 13. Cell Death Differ. 2012. PMID: 22790873 Free PMC article.
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