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The transient receptor potential (TRP) channel TRPC3 TRP domain and AMP-activated protein kinase binding site are required for TRPC3 activation by erythropoietin.
Hirschler-Laszkiewicz I, Tong Q, Waybill K, Conrad K, Keefer K, Zhang W, Chen SJ, Cheung JY, Miller BA. Hirschler-Laszkiewicz I, et al. Among authors: chen sj. J Biol Chem. 2011 Sep 2;286(35):30636-30646. doi: 10.1074/jbc.M111.238360. Epub 2011 Jul 14. J Biol Chem. 2011. PMID: 21757714 Free PMC article.
Trpc2 depletion protects red blood cells from oxidative stress-induced hemolysis.
Hirschler-Laszkiewicz I, Zhang W, Keefer K, Conrad K, Tong Q, Chen SJ, Bronson S, Cheung JY, Miller BA. Hirschler-Laszkiewicz I, et al. Among authors: chen sj. Exp Hematol. 2012 Jan;40(1):71-83. doi: 10.1016/j.exphem.2011.09.006. Epub 2011 Sep 14. Exp Hematol. 2012. PMID: 21924222 Free PMC article.
A splice variant of the human ion channel TRPM2 modulates neuroblastoma tumor growth through hypoxia-inducible factor (HIF)-1/2α.
Chen SJ, Hoffman NE, Shanmughapriya S, Bao L, Keefer K, Conrad K, Merali S, Takahashi Y, Abraham T, Hirschler-Laszkiewicz I, Wang J, Zhang XQ, Song J, Barrero C, Shi Y, Kawasawa YI, Bayerl M, Sun T, Barbour M, Wang HG, Madesh M, Cheung JY, Miller BA. Chen SJ, et al. J Biol Chem. 2014 Dec 26;289(52):36284-302. doi: 10.1074/jbc.M114.620922. Epub 2014 Nov 12. J Biol Chem. 2014. PMID: 25391657 Free PMC article.
Depletion of the Human Ion Channel TRPM2 in Neuroblastoma Demonstrates Its Key Role in Cell Survival through Modulation of Mitochondrial Reactive Oxygen Species and Bioenergetics.
Bao L, Chen SJ, Conrad K, Keefer K, Abraham T, Lee JP, Wang J, Zhang XQ, Hirschler-Laszkiewicz I, Wang HG, Dovat S, Gans B, Madesh M, Cheung JY, Miller BA. Bao L, et al. Among authors: chen sj. J Biol Chem. 2016 Nov 18;291(47):24449-24464. doi: 10.1074/jbc.M116.747147. Epub 2016 Sep 30. J Biol Chem. 2016. PMID: 27694440 Free PMC article.
Role of TRPM2 in cell proliferation and susceptibility to oxidative stress.
Chen SJ, Zhang W, Tong Q, Conrad K, Hirschler-Laszkiewicz I, Bayerl M, Kim JK, Cheung JY, Miller BA. Chen SJ, et al. Am J Physiol Cell Physiol. 2013 Mar;304(6):C548-60. doi: 10.1152/ajpcell.00069.2012. Epub 2013 Jan 9. Am J Physiol Cell Physiol. 2013. PMID: 23302782 Free PMC article.
The second member of transient receptor potential-melastatin channel family protects hearts from ischemia-reperfusion injury.
Miller BA, Wang J, Hirschler-Laszkiewicz I, Gao E, Song J, Zhang XQ, Koch WJ, Madesh M, Mallilankaraman K, Gu T, Chen SJ, Keefer K, Conrad K, Feldman AM, Cheung JY. Miller BA, et al. Among authors: chen sj. Am J Physiol Heart Circ Physiol. 2013 Apr 1;304(7):H1010-22. doi: 10.1152/ajpheart.00906.2012. Epub 2013 Feb 1. Am J Physiol Heart Circ Physiol. 2013. PMID: 23376831 Free PMC article.
The human ion channel TRPM2 modulates neuroblastoma cell survival and mitochondrial function through Pyk2, CREB, and MCU activation.
Hirschler-Laszkiewicz I, Chen SJ, Bao L, Wang J, Zhang XQ, Shanmughapriya S, Keefer K, Madesh M, Cheung JY, Miller BA. Hirschler-Laszkiewicz I, et al. Among authors: chen sj. Am J Physiol Cell Physiol. 2018 Oct 1;315(4):C571-C586. doi: 10.1152/ajpcell.00098.2018. Epub 2018 Jul 18. Am J Physiol Cell Physiol. 2018. PMID: 30020827 Free PMC article.
Transient receptor potential ion channel TRPM2 promotes AML proliferation and survival through modulation of mitochondrial function, ROS, and autophagy.
Chen SJ, Bao L, Keefer K, Shanmughapriya S, Chen L, Lee J, Wang J, Zhang XQ, Hirschler-Laszkiewicz I, Merali S, Merali C, Imamura Y, Dovat S, Madesh M, Cheung JY, Wang HG, Miller BA. Chen SJ, et al. Among authors: chen l. Cell Death Dis. 2020 Apr 20;11(4):247. doi: 10.1038/s41419-020-2454-8. Cell Death Dis. 2020. PMID: 32312983 Free PMC article.
3,033 results