Sporn MB - Search Results

1

Proteomic analysis shows synthetic oleanane triterpenoid binds to mTOR.

Yore MM, Kettenbach AN, Sporn MB, Gerber SA, Liby KT. Yore MM, et al. Among authors: sporn mb. PLoS One. 2011;6(7):e22862. doi: 10.1371/journal.pone.0022862. Epub 2011 Jul 27. PLoS One. 2011. PMID: 21818401 Free PMC article.

2

The synthetic triterpenoid 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole blocks nuclear factor-kappaB activation through direct inhibition of IkappaB kinase beta.

Yore MM, Liby KT, Honda T, Gribble GW, Sporn MB. Yore MM, et al. Among authors: sporn mb. Mol Cancer Ther. 2006 Dec;5(12):3232-9. doi: 10.1158/1535-7163.MCT-06-0444. Epub 2006 Dec 5. Mol Cancer Ther. 2006. PMID: 17148759

3

The rexinoid LG100268 and the synthetic triterpenoid CDDO-methyl amide are more potent than erlotinib for prevention of mouse lung carcinogenesis.

Liby K, Black CC, Royce DB, Williams CR, Risingsong R, Yore MM, Liu X, Honda T, Gribble GW, Lamph WW, Sporn TA, Dmitrovsky E, Sporn MB. Liby K, et al. Among authors: sporn mb, sporn ta. Mol Cancer Ther. 2008 May;7(5):1251-7. doi: 10.1158/1535-7163.MCT-08-0023. Mol Cancer Ther. 2008. PMID: 18483313 Free PMC article.

4

New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress.

Sporn MB, Liby KT, Yore MM, Fu L, Lopchuk JM, Gribble GW. Sporn MB, et al. J Nat Prod. 2011 Mar 25;74(3):537-45. doi: 10.1021/np100826q. Epub 2011 Feb 10. J Nat Prod. 2011. PMID: 21309592 Free PMC article. Review.

5

Synthetic oleanane triterpenoids: multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease.

Liby KT, Sporn MB. Liby KT, et al. Among authors: sporn mb. Pharmacol Rev. 2012 Oct;64(4):972-1003. doi: 10.1124/pr.111.004846. Epub 2012 Sep 10. Pharmacol Rev. 2012. PMID: 22966038 Free PMC article. Review.

6

A synthetic triterpenoid CDDO-Im inhibits tumorsphere formation by regulating stem cell signaling pathways in triple-negative breast cancer.

So JY, Lin JJ, Wahler J, Liby KT, Sporn MB, Suh N. So JY, et al. Among authors: sporn mb. PLoS One. 2014 Sep 17;9(9):e107616. doi: 10.1371/journal.pone.0107616. eCollection 2014. PLoS One. 2014. PMID: 25229616 Free PMC article.

7

Synthetic triterpenoids attenuate cytotoxic retinal injury: cross-talk between Nrf2 and PI3K/AKT signaling through inhibition of the lipid phosphatase PTEN.

Pitha-Rowe I, Liby K, Royce D, Sporn M. Pitha-Rowe I, et al. Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5339-47. doi: 10.1167/iovs.09-3648. Epub 2009 Jun 3. Invest Ophthalmol Vis Sci. 2009. PMID: 19494206

8

Synthetic oleanane triterpenoids enhance blood brain barrier integrity and improve survival in experimental cerebral malaria.

Crowley VM, Ayi K, Lu Z, Liby KT, Sporn M, Kain KC. Crowley VM, et al. Malar J. 2017 Nov 14;16(1):463. doi: 10.1186/s12936-017-2109-0. Malar J. 2017. PMID: 29137631 Free PMC article.

9

Design, synthesis, and biological evaluation of biotin conjugates of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid for the isolation of the protein targets.

Honda T, Janosik T, Honda Y, Han J, Liby KT, Williams CR, Couch RD, Anderson AC, Sporn MB, Gribble GW. Honda T, et al. Among authors: sporn mb. J Med Chem. 2004 Sep 23;47(20):4923-32. doi: 10.1021/jm049727e. J Med Chem. 2004. PMID: 15369396

10

The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling.

Liby K, Hock T, Yore MM, Suh N, Place AE, Risingsong R, Williams CR, Royce DB, Honda T, Honda Y, Gribble GW, Hill-Kapturczak N, Agarwal A, Sporn MB. Liby K, et al. Among authors: sporn mb. Cancer Res. 2005 Jun 1;65(11):4789-98. doi: 10.1158/0008-5472.CAN-04-4539. Cancer Res. 2005. PMID: 15930299

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