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Drug design structural alert: formation of trifluoroacetaldehyde through N-dealkylation is linked to testicular lesions in rat.
Int J Toxicol. 2011 Oct;30(5):546-50. doi: 10.1177/1091581811413833. Epub 2011 Aug 25.
Int J Toxicol. 2011.
PMID: 21868768
Rational approach to highly potent and selective apoptosis signal-regulating kinase 1 (ASK1) inhibitors.
Lovering F, Morgan P, Allais C, Aulabaugh A, Brodfuehrer J, Chang J, Coe J, Ding W, Dowty H, Fleming M, Frisbie R, Guzova J, Hepworth D, Jasti J, Kortum S, Kurumbail R, Mohan S, Papaioannou N, Strohbach JW, Vincent F, Lee K, Zapf CW.
Lovering F, et al.
Eur J Med Chem. 2018 Feb 10;145:606-621. doi: 10.1016/j.ejmech.2017.12.041. Epub 2017 Dec 15.
Eur J Med Chem. 2018.
PMID: 29348070
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Spontaneous Axonal Dystrophy in the Brain and Spinal Cord in Naïve Beagle Dogs.
Pardo ID, Otis D, Ritenour HN, Bailey S, Masek-Hammerman K, Dowty HV, Bolon B, Palazzi X.
Pardo ID, et al. Among authors: dowty hv.
Toxicol Pathol. 2020 Jul;48(5):694-701. doi: 10.1177/0192623320926475. Epub 2020 Jun 1.
Toxicol Pathol. 2020.
PMID: 32476609
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Reduction of a 7,12-dimethylbenz[a]anthracene DNA adduct in rat mammary tissue in vivo when pretreated with tamoxifen.
Warshawsky D, Dowty HV, LaDow K, Succop P, Talaska G.
Warshawsky D, et al. Among authors: dowty hv.
Toxicol Lett. 2002 Jun 7;132(1):71-9. doi: 10.1016/s0378-4274(02)00069-3.
Toxicol Lett. 2002.
PMID: 12084622
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One-electron oxidation is not a major route of metabolic activation and DNA binding for the carcinogen 7H-dibenzo[c,g]carbazole in vitro and in mouse liver and lung.
Dowty HV, Xue W, LaDow K, Talaska G, Warshawsky D.
Dowty HV, et al.
Carcinogenesis. 2000 May;21(5):991-8. doi: 10.1093/carcin/21.5.991.
Carcinogenesis. 2000.
PMID: 10783323
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Combination of high-performance liquid chromatography and thin-layer chromatography separation of five adducted nucleotides isolated from liver resulting from intraperitoneal administration with 7H-dibenzo[c,g]carbazole to mice.
O'Connor P, Fremont S, Schneider J, Dowty H, Jaeger M, Talaska G, Warshawsky D.
O'Connor P, et al.
J Chromatogr B Biomed Sci Appl. 1997 Oct 24;700(1-2):49-57. doi: 10.1016/s0378-4347(97)00316-2.
J Chromatogr B Biomed Sci Appl. 1997.
PMID: 9390713
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A phase I, randomized, double-blind study to assess the safety, tolerability and efficacy of the topical RORC2 inverse agonist PF-06763809 in participants with mild-to-moderate plaque psoriasis.
Berstein G, Zhang Y, Berger Z, Kieras E, Li G, Samuel A, Yeoh T, Dowty H, Beaumont K, Wigger-Alberti W, von Mackensen Y, Kroencke U, Hamscho R, Garcet S, Krueger JG, Banfield C, Oemar B.
Berstein G, et al.
Clin Exp Dermatol. 2021 Jan;46(1):122-129. doi: 10.1111/ced.14412. Epub 2020 Sep 14.
Clin Exp Dermatol. 2021.
PMID: 32767679
Free PMC article.
Clinical Trial.
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