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Sensing damage by the NLRP3 inflammasome.
Leemans JC, Cassel SL, Sutterwala FS. Leemans JC, et al. Immunol Rev. 2011 Sep;243(1):152-62. doi: 10.1111/j.1600-065X.2011.01043.x. Immunol Rev. 2011. PMID: 21884174 Free PMC article. Review.
Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome.
Iyer SS, Pulskens WP, Sadler JJ, Butter LM, Teske GJ, Ulland TK, Eisenbarth SC, Florquin S, Flavell RA, Leemans JC, Sutterwala FS. Iyer SS, et al. Among authors: leemans jc. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20388-93. doi: 10.1073/pnas.0908698106. Epub 2009 Nov 16. Proc Natl Acad Sci U S A. 2009. PMID: 19918053 Free PMC article.
Ventilator-induced lung injury is mediated by the NLRP3 inflammasome.
Kuipers MT, Aslami H, Janczy JR, van der Sluijs KF, Vlaar AP, Wolthuis EK, Choi G, Roelofs JJ, Flavell RA, Sutterwala FS, Bresser P, Leemans JC, van der Poll T, Schultz MJ, Wieland CW. Kuipers MT, et al. Among authors: leemans jc. Anesthesiology. 2012 May;116(5):1104-15. doi: 10.1097/ALN.0b013e3182518bc0. Anesthesiology. 2012. PMID: 22531249 Free article.
Nlrp3 plays no role in acute cardiac infarction due to low cardiac expression.
Jong WM, Leemans JC, Weber NC, Juffermans NP, Schultz MJ, Hollmann MW, Zuurbier CJ. Jong WM, et al. Among authors: leemans jc. Int J Cardiol. 2014 Nov 15;177(1):41-3. doi: 10.1016/j.ijcard.2014.09.148. Epub 2014 Oct 10. Int J Cardiol. 2014. PMID: 25499334 No abstract available.
97 results