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Discovery of two clinical histamine H(3) receptor antagonists: trans-N-ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidinylmethyl)phenyl]cyclobutanecarboxamide (PF-03654746) and trans-3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]-N-(2-methylpropyl)cyclobutanecarboxamide (PF-03654764).
J Med Chem. 2011 Nov 10;54(21):7602-20. doi: 10.1021/jm200939b. Epub 2011 Oct 7.
J Med Chem. 2011.
PMID: 21928839
Pharmaceutical impurity identification: a case study using a multidisciplinary approach.
Alsante KM, Boutros P, Couturier MA, Friedmann RC, Harwood JW, Horan GJ, Jensen AJ, Liu Q, Lohr LL, Morris R, Raggon JW, Reid GL, Santafianos DP, Sharp TR, Tucker JL, Wilcox GE.
Alsante KM, et al. Among authors: raggon jw.
J Pharm Sci. 2004 Sep;93(9):2296-309. doi: 10.1002/jps.20120.
J Pharm Sci. 2004.
PMID: 15295790
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Furan-Terminated N-Acyliminium Ion Initiated Cyclizations in Alkaloid Synthesis.
Tanis SP, Deaton MV, Dixon LA, McMills MC, Raggon JW, Collins MA.
Tanis SP, et al. Among authors: raggon jw.
J Org Chem. 1998 Oct 2;63(20):6914-6928. doi: 10.1021/jo980718l.
J Org Chem. 1998.
PMID: 11672313
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