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A phase II, multicenter, open-label study evaluating dosing and preliminary safety and efficacy of canakinumab in systemic juvenile idiopathic arthritis with active systemic features.
Ruperto N, Quartier P, Wulffraat N, Woo P, Ravelli A, Mouy R, Bader-Meunier B, Vastert SJ, Noseda E, D'Ambrosio D, Lecot J, Chakraborty A, Martini A, Chioato A; Paediatric Rheumatology International Clinical Trials Organisation. Ruperto N, et al. Among authors: vastert sj. Arthritis Rheum. 2012 Feb;64(2):557-67. doi: 10.1002/art.33342. Arthritis Rheum. 2012. PMID: 21953497 Free article. Clinical Trial.
Human TH17 cells engage gasdermin E pores to release IL-1α on NLRP3 inflammasome activation.
Chao YY, Puhach A, Frieser D, Arunkumar M, Lehner L, Seeholzer T, Garcia-Lopez A, van der Wal M, Fibi-Smetana S, Dietschmann A, Sommermann T, Ćiković T, Taher L, Gresnigt MS, Vastert SJ, van Wijk F, Panagiotou G, Krappmann D, Groß O, Zielinski CE. Chao YY, et al. Among authors: vastert sj. Nat Immunol. 2023 Feb;24(2):295-308. doi: 10.1038/s41590-022-01386-w. Epub 2023 Jan 5. Nat Immunol. 2023. PMID: 36604548 Free PMC article.
Mutations in the perforin gene can be linked to macrophage activation syndrome in patients with systemic onset juvenile idiopathic arthritis.
Vastert SJ, van Wijk R, D'Urbano LE, de Vooght KM, de Jager W, Ravelli A, Magni-Manzoni S, Insalaco A, Cortis E, van Solinge WW, Prakken BJ, Wulffraat NM, de Benedetti F, Kuis W. Vastert SJ, et al. Rheumatology (Oxford). 2010 Mar;49(3):441-9. doi: 10.1093/rheumatology/kep418. Epub 2009 Dec 17. Rheumatology (Oxford). 2010. PMID: 20019066
114 results