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Two genes, rif15 and rif16, of the rifamycin biosynthetic gene cluster in Amycolatopsis mediterranei likely encode a transketolase and a P450 monooxygenase, respectively, both essential for the conversion of rifamycin SV into B.
Yuan H, Zhao W, Zhong Y, Wang J, Qin Z, Ding X, Zhao GP. Yuan H, et al. Among authors: ding x. Acta Biochim Biophys Sin (Shanghai). 2011 Dec;43(12):948-56. doi: 10.1093/abbs/gmr091. Epub 2011 Oct 10. Acta Biochim Biophys Sin (Shanghai). 2011. PMID: 21986914 Free article.
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.
Zhao W, Zhong Y, Yuan H, Wang J, Zheng H, Wang Y, Cen X, Xu F, Bai J, Han X, Lu G, Zhu Y, Shao Z, Yan H, Li C, Peng N, Zhang Z, Zhang Y, Lin W, Fan Y, Qin Z, Hu Y, Zhu B, Wang S, Ding X, Zhao GP. Zhao W, et al. Among authors: ding x. Cell Res. 2010 Oct;20(10):1096-108. doi: 10.1038/cr.2010.87. Epub 2010 Jun 22. Cell Res. 2010. PMID: 20567260
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