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Disruption of the Ah receptor gene alters the susceptibility of mice to oxygen-mediated regulation of pulmonary and hepatic cytochromes P4501A expression and exacerbates hyperoxic lung injury.
Jiang W, Welty SE, Couroucli XI, Barrios R, Kondraganti SR, Muthiah K, Yu L, Avery SE, Moorthy B. Jiang W, et al. Among authors: couroucli xi. J Pharmacol Exp Ther. 2004 Aug;310(2):512-9. doi: 10.1124/jpet.103.059766. Epub 2004 May 3. J Pharmacol Exp Ther. 2004. PMID: 15123765
Disruption of the gene for CYP1A2, which is expressed primarily in liver, leads to differential regulation of hepatic and pulmonary mouse CYP1A1 expression and augmented human CYP1A1 transcriptional activation in response to 3-methylcholanthrene in vivo.
Jiang W, Wang L, Kondraganti SR, Fazili IS, Couroucli XI, Felix EA, Moorthy B. Jiang W, et al. Among authors: couroucli xi. J Pharmacol Exp Ther. 2010 Nov;335(2):369-79. doi: 10.1124/jpet.110.171173. Epub 2010 Aug 23. J Pharmacol Exp Ther. 2010. PMID: 20732958 Free PMC article.
Augmented oxygen-mediated transcriptional activation of cytochrome P450 (CYP)1A expression and increased susceptibilities to hyperoxic lung injury in transgenic mice carrying the human CYP1A1 or mouse 1A2 promoter in vivo.
Jiang W, Couroucli XI, Wang L, Barrios R, Moorthy B. Jiang W, et al. Among authors: couroucli xi. Biochem Biophys Res Commun. 2011 Apr 1;407(1):79-85. doi: 10.1016/j.bbrc.2011.02.113. Epub 2011 Mar 6. Biochem Biophys Res Commun. 2011. PMID: 21362406 Free PMC article.
38 results