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Hydroxylated analogues of ATP-sensitive potassium channel openers belonging to the group of 6- and/or 7-substituted 3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides: toward an improvement in sulfonylurea receptor 1 selectivity and metabolism stability.
J Med Chem. 2011 Dec 22;54(24):8353-61. doi: 10.1021/jm200786z. Epub 2011 Nov 29.
J Med Chem. 2011.
PMID: 22077416
Coupling of liquid chromatography/tandem mass spectrometry and liquid chromatography/solid-phase extraction/NMR techniques for the structural identification of metabolites following in vitro biotransformation of SUR1-selective ATP-sensitive potassium channel openers.
Gillotin F, Chiap P, Frédérich M, Van Heugen JC, Francotte P, Lebrun P, Pirotte B, de Tullio P.
Gillotin F, et al.
Drug Metab Dispos. 2010 Feb;38(2):232-40. doi: 10.1124/dmd.109.028928. Epub 2009 Oct 29.
Drug Metab Dispos. 2010.
PMID: 19875500
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New fluorinated 1,2,4-benzothiadiazine 1,1-dioxides: discovery of an orally active cognitive enhancer acting through potentiation of the 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors.
Francotte P, Goffin E, Fraikin P, Lestage P, Van Heugen JC, Gillotin F, Danober L, Thomas JY, Chiap P, Caignard DH, Pirotte B, de Tullio P.
Francotte P, et al. Among authors: gillotin f.
J Med Chem. 2010 Feb 25;53(4):1700-11. doi: 10.1021/jm901495t.
J Med Chem. 2010.
PMID: 20108934
Free article.
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Generic systems for the enantioseparation of basic drugs in NACE using single-isomer anionic CDs.
Rousseau A, Gillotin F, Chiap P, Bodoki E, Crommen J, Fillet M, Servais AC.
Rousseau A, et al. Among authors: gillotin f.
J Pharm Biomed Anal. 2011 Jan 5;54(1):154-9. doi: 10.1016/j.jpba.2010.08.004. Epub 2010 Aug 13.
J Pharm Biomed Anal. 2011.
PMID: 20828966
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Association of two single-isomer anionic CD in NACE for the chiral and achiral separation of fenbendazole, its sulphoxide and sulphone metabolites: application to their determination after in vitro metabolism.
Rousseau A, Gillotin F, Chiap P, Crommen J, Fillet M, Servais AC.
Rousseau A, et al. Among authors: gillotin f.
Electrophoresis. 2010 May;31(9):1482-7. doi: 10.1002/elps.200900723.
Electrophoresis. 2010.
PMID: 20376816
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Deciphering the factors defining the pH-dependence of a commercial glycoside hydrolase family 8 enzyme.
Barroca M, Santos G, Johansson B, Gillotin F, Feller G, Collins T.
Barroca M, et al. Among authors: gillotin f.
Enzyme Microb Technol. 2017 Jan;96:163-169. doi: 10.1016/j.enzmictec.2016.10.011. Epub 2016 Oct 17.
Enzyme Microb Technol. 2017.
PMID: 27871378
Free article.
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