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Five years of denosumab exposure in women with postmenopausal osteoporosis: results from the first two years of the FREEDOM extension.
Papapoulos S, Chapurlat R, Libanati C, Brandi ML, Brown JP, Czerwiński E, Krieg MA, Man Z, Mellström D, Radominski SC, Reginster JY, Resch H, Román Ivorra JA, Roux C, Vittinghoff E, Austin M, Daizadeh N, Bradley MN, Grauer A, Cummings SR, Bone HG. Papapoulos S, et al. Among authors: bradley mn. J Bone Miner Res. 2012 Mar;27(3):694-701. doi: 10.1002/jbmr.1479. J Bone Miner Res. 2012. PMID: 22113951 Free PMC article. Clinical Trial.
The effect of three or six years of denosumab exposure in women with postmenopausal osteoporosis: results from the FREEDOM extension.
Bone HG, Chapurlat R, Brandi ML, Brown JP, Czerwinski E, Krieg MA, Mellström D, Radominski SC, Reginster JY, Resch H, Ivorra JA, Roux C, Vittinghoff E, Daizadeh NS, Wang A, Bradley MN, Franchimont N, Geller ML, Wagman RB, Cummings SR, Papapoulos S. Bone HG, et al. Among authors: bradley mn. J Clin Endocrinol Metab. 2013 Nov;98(11):4483-92. doi: 10.1210/jc.2013-1597. Epub 2013 Aug 26. J Clin Endocrinol Metab. 2013. PMID: 23979955 Free PMC article. Clinical Trial.
10 years of denosumab treatment in postmenopausal women with osteoporosis: results from the phase 3 randomised FREEDOM trial and open-label extension.
Bone HG, Wagman RB, Brandi ML, Brown JP, Chapurlat R, Cummings SR, Czerwiński E, Fahrleitner-Pammer A, Kendler DL, Lippuner K, Reginster JY, Roux C, Malouf J, Bradley MN, Daizadeh NS, Wang A, Dakin P, Pannacciulli N, Dempster DW, Papapoulos S. Bone HG, et al. Among authors: bradley mn. Lancet Diabetes Endocrinol. 2017 Jul;5(7):513-523. doi: 10.1016/S2213-8587(17)30138-9. Epub 2017 May 22. Lancet Diabetes Endocrinol. 2017. PMID: 28546097 Clinical Trial.
LXRα is uniquely required for maximal reverse cholesterol transport and atheroprotection in ApoE-deficient mice.
Hong C, Bradley MN, Rong X, Wang X, Wagner A, Grijalva V, Castellani LW, Salazar J, Realegeno S, Boyadjian R, Fogelman AM, Van Lenten BJ, Reddy ST, Lusis AJ, Tangirala RK, Tontonoz P. Hong C, et al. Among authors: bradley mn. J Lipid Res. 2012 Jun;53(6):1126-33. doi: 10.1194/jlr.M022061. Epub 2012 Mar 26. J Lipid Res. 2012. PMID: 22454476 Free PMC article.
LXR promotes the maximal egress of monocyte-derived cells from mouse aortic plaques during atherosclerosis regression.
Feig JE, Pineda-Torra I, Sanson M, Bradley MN, Vengrenyuk Y, Bogunovic D, Gautier EL, Rubinstein D, Hong C, Liu J, Wu C, van Rooijen N, Bhardwaj N, Garabedian M, Tontonoz P, Fisher EA. Feig JE, et al. Among authors: bradley mn. J Clin Invest. 2010 Dec;120(12):4415-24. doi: 10.1172/JCI38911. J Clin Invest. 2010. PMID: 21041949 Free PMC article.
Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR.
A-Gonzalez N, Bensinger SJ, Hong C, Beceiro S, Bradley MN, Zelcer N, Deniz J, Ramirez C, Díaz M, Gallardo G, de Galarreta CR, Salazar J, Lopez F, Edwards P, Parks J, Andujar M, Tontonoz P, Castrillo A. A-Gonzalez N, et al. Among authors: bradley mn. Immunity. 2009 Aug 21;31(2):245-58. doi: 10.1016/j.immuni.2009.06.018. Epub 2009 Jul 30. Immunity. 2009. PMID: 19646905 Free PMC article.
T0901317, an LXR agonist, augments PKA-induced vascular cell calcification.
Hsu JJ, Lu J, Huang MS, Geng Y, Sage AP, Bradley MN, Tontonoz P, Demer LL, Tintut Y. Hsu JJ, et al. Among authors: bradley mn. FEBS Lett. 2009 Apr 17;583(8):1344-8. doi: 10.1016/j.febslet.2009.03.039. Epub 2009 Mar 25. FEBS Lett. 2009. PMID: 19327357 Free PMC article.
28 results