Zhao ZJ - Search Results

1

The Jak2 inhibitor, G6, alleviates Jak2-V617F-mediated myeloproliferative neoplasia by providing significant therapeutic efficacy to the bone marrow.

Kirabo A, Park SO, Majumder A, Gali M, Reinhard MK, Wamsley HL, Zhao ZJ, Cogle CR, Bisht KS, Keserü GM, Sayeski PP. Kirabo A, et al. Among authors: zhao zj. Neoplasia. 2011 Nov;13(11):1058-68. doi: 10.1593/neo.111112. Neoplasia. 2011. PMID: 22131881 Free PMC article.

2

A46, a benzothiophene-derived compound, suppresses Jak2-mediated pathologic cell growth.

Majumder A, Magis AT, Park SO, Figueroa NC, Baskin R, Kirabo A, Allan RW, Zhao ZJ, Bisht KS, Keseru GM, Sayeski PP. Majumder A, et al. Among authors: zhao zj. Exp Hematol. 2012 Jan;40(1):22-34. doi: 10.1016/j.exphem.2011.10.003. Epub 2011 Oct 20. Exp Hematol. 2012. PMID: 22019628 Free PMC article.

3

Identification of novel SAR properties of the Jak2 small molecule inhibitor G6: significance of the para-hydroxyl orientation.

Baskin R, Gali M, Park SO, Zhao ZJ, Keseru GM, Bisht KS, Sayeski PP. Baskin R, et al. Among authors: zhao zj. Bioorg Med Chem Lett. 2012 Feb 1;22(3):1402-7. doi: 10.1016/j.bmcl.2011.12.042. Epub 2011 Dec 21. Bioorg Med Chem Lett. 2012. PMID: 22227213 Free PMC article.

4

The small molecule inhibitor G6 significantly reduces bone marrow fibrosis and the mutant burden in a mouse model of Jak2-mediated myelofibrosis.

Kirabo A, Park SO, Wamsley HL, Gali M, Baskin R, Reinhard MK, Zhao ZJ, Bisht KS, Keserű GM, Cogle CR, Sayeski PP. Kirabo A, et al. Among authors: zhao zj. Am J Pathol. 2012 Sep;181(3):858-65. doi: 10.1016/j.ajpath.2012.05.033. Epub 2012 Jul 13. Am J Pathol. 2012. PMID: 22796437 Free PMC article.

5

Elevated levels of mast cells are involved in pruritus associated with polycythemia vera in JAK2V617F transgenic mice.

Jin X, Zhao W, Kirabo A, Park SO, Ho WT, Sayeski PP, Zhao ZJ. Jin X, et al. Among authors: zhao w, zhao zj. J Immunol. 2014 Jul 15;193(2):477-84. doi: 10.4049/jimmunol.1301946. Epub 2014 Jun 11. J Immunol. 2014. PMID: 24920845

6

miR-543 regulates the epigenetic landscape of myelofibrosis by targeting TET1 and TET2.

Fuentes-Mattei E, Bayraktar R, Manshouri T, Silva AM, Ivan C, Gulei D, Fabris L, Soares do Amaral N, Mur P, Perez C, Torres-Claudio E, Dragomir MP, Badillo-Perez A, Knutsen E, Narayanan P, Golfman L, Shimizu M, Zhang X, Zhao W, Ho WT, Estecio MR, Bartholomeusz G, Tomuleasa C, Berindan-Neagoe I, Zweidler-McKay PA, Estrov Z, Zhao ZJ, Verstovsek S, Calin GA, Redis RS. Fuentes-Mattei E, et al. Among authors: zhao w, zhao zj. JCI Insight. 2020 Jan 16;5(1):e121781. doi: 10.1172/jci.insight.121781. JCI Insight. 2020. PMID: 31941838 Free PMC article.

7

JAK2(V617F): Prevalence in a large Chinese hospital population.

Xu X, Zhang Q, Luo J, Xing S, Li Q, Krantz SB, Fu X, Zhao ZJ. Xu X, et al. Among authors: zhao zj. Blood. 2007 Jan 1;109(1):339-42. doi: 10.1182/blood-2006-03-009472. Epub 2006 Aug 31. Blood. 2007. PMID: 16946305 Free PMC article.

8

Efficacy of ALK5 inhibition in myelofibrosis.

Yue L, Bartenstein M, Zhao W, Ho WT, Han Y, Murdun C, Mailloux AW, Zhang L, Wang X, Budhathoki A, Pradhan K, Rapaport F, Wang H, Shao Z, Ren X, Steidl U, Levine RL, Zhao ZJ, Verma A, Epling-Burnette PK. Yue L, et al. Among authors: zhao w, zhao zj. JCI Insight. 2017 Apr 6;2(7):e90932. doi: 10.1172/jci.insight.90932. JCI Insight. 2017. PMID: 28405618 Free PMC article.

9

Transgenic expression of JAK2V617F causes myeloproliferative disorders in mice.

Xing S, Wanting TH, Zhao W, Ma J, Wang S, Xu X, Li Q, Fu X, Xu M, Zhao ZJ. Xing S, et al. Among authors: zhao w, zhao zj. Blood. 2008 May 15;111(10):5109-17. doi: 10.1182/blood-2007-05-091579. Epub 2008 Mar 11. Blood. 2008. PMID: 18334677 Free PMC article.

10

Characterization of a highly effective protein substrate for analysis of JAK2(V617F) Activity.

Li Z, Xing S, Wang S, Ho WT, Zhao ZJ. Li Z, et al. Among authors: zhao zj. Exp Hematol. 2007 Nov;35(11):1624-32. doi: 10.1016/j.exphem.2007.07.003. Epub 2007 Aug 30. Exp Hematol. 2007. PMID: 17764811 Free PMC article.

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