Lawrence N - Search Results

1

TNF-α-mediated proliferation of vascular smooth muscle cells involves Raf-1-mediated inactivation of Rb and transcription of E2F1-regulated genes.

Davis R, Pillai S, Lawrence N, Sebti S, Chellappan SP. Davis R, et al. Among authors: lawrence n. Cell Cycle. 2012 Jan 1;11(1):109-18. doi: 10.4161/cc.11.1.18473. Epub 2012 Jan 1. Cell Cycle. 2012. PMID: 22185776 Free PMC article.

2

Discovery of a novel shp2 protein tyrosine phosphatase inhibitor.

Chen L, Sung SS, Yip ML, Lawrence HR, Ren Y, Guida WC, Sebti SM, Lawrence NJ, Wu J. Chen L, et al. Mol Pharmacol. 2006 Aug;70(2):562-70. doi: 10.1124/mol.106.025536. Epub 2006 May 22. Mol Pharmacol. 2006. PMID: 16717135

3

Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity.

Siddiquee K, Zhang S, Guida WC, Blaskovich MA, Greedy B, Lawrence HR, Yip ML, Jove R, McLaughlin MM, Lawrence NJ, Sebti SM, Turkson J. Siddiquee K, et al. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7391-6. doi: 10.1073/pnas.0609757104. Epub 2007 Apr 26. Proc Natl Acad Sci U S A. 2007. PMID: 17463090 Free PMC article.

4

A small molecule disruptor of Rb/Raf-1 interaction inhibits cell proliferation, angiogenesis, and growth of human tumor xenografts in nude mice.

Kinkade R, Dasgupta P, Carie A, Pernazza D, Carless M, Pillai S, Lawrence N, Sebti SM, Chellappan S. Kinkade R, et al. Among authors: lawrence n. Cancer Res. 2008 May 15;68(10):3810-8. doi: 10.1158/0008-5472.CAN-07-6672. Cancer Res. 2008. PMID: 18483265 Free PMC article.

5

Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds.

Lawrence HR, Pireddu R, Chen L, Luo Y, Sung SS, Szymanski AM, Yip ML, Guida WC, Sebti SM, Wu J, Lawrence NJ. Lawrence HR, et al. J Med Chem. 2008 Aug 28;51(16):4948-56. doi: 10.1021/jm8002526. Epub 2008 Aug 5. J Med Chem. 2008. PMID: 18680359 Free PMC article.

6

Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins.

Wei J, Kitada S, Rega MF, Emdadi A, Yuan H, Cellitti J, Stebbins JL, Zhai D, Sun J, Yang L, Dahl R, Zhang Z, Wu B, Wang S, Reed TA, Wang HG, Lawrence N, Sebti S, Reed JC, Pellecchia M. Wei J, et al. Among authors: lawrence n. Mol Cancer Ther. 2009 Apr;8(4):904-13. doi: 10.1158/1535-7163.MCT-08-1050. Mol Cancer Ther. 2009. PMID: 19372563 Free PMC article.

7

Identification of a disruptor of the MDM2-p53 protein-protein interaction facilitated by high-throughput in silico docking.

Lawrence HR, Li Z, Yip ML, Sung SS, Lawrence NJ, McLaughlin ML, McManus GJ, Zaworotko MJ, Sebti SM, Chen J, Guida WC. Lawrence HR, et al. Bioorg Med Chem Lett. 2009 Jul 15;19(14):3756-9. doi: 10.1016/j.bmcl.2009.04.124. Epub 2009 May 3. Bioorg Med Chem Lett. 2009. PMID: 19457663 Free PMC article.

8

Targeting protein tyrosine phosphatases for anticancer drug discovery.

Scott LM, Lawrence HR, Sebti SM, Lawrence NJ, Wu J. Scott LM, et al. Curr Pharm Des. 2010 Jun;16(16):1843-62. doi: 10.2174/138161210791209027. Curr Pharm Des. 2010. PMID: 20337577 Free PMC article. Review.

9

The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane.

Berndt N, Yang H, Trinczek B, Betzi S, Zhang Z, Wu B, Lawrence NJ, Pellecchia M, Schönbrunn E, Cheng JQ, Sebti SM. Berndt N, et al. Among authors: lawrence nj. Cell Death Differ. 2010 Nov;17(11):1795-804. doi: 10.1038/cdd.2010.63. Epub 2010 May 21. Cell Death Differ. 2010. PMID: 20489726 Free PMC article.

10

Inhibition of cellular Shp2 activity by a methyl ester analog of SPI-112.

Chen L, Pernazza D, Scott LM, Lawrence HR, Ren Y, Luo Y, Wu X, Sung SS, Guida WC, Sebti SM, Lawrence NJ, Wu J. Chen L, et al. Biochem Pharmacol. 2010 Sep 15;80(6):801-10. doi: 10.1016/j.bcp.2010.05.019. Epub 2010 May 25. Biochem Pharmacol. 2010. PMID: 20510203 Free PMC article.

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