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Cooperativity of RUNX1 and CSF3R mutations in severe congenital neutropenia: a unique pathway in myeloid leukemogenesis.
Skokowa J, Steinemann D, Katsman-Kuipers JE, Zeidler C, Klimenkova O, Klimiankou M, Unalan M, Kandabarau S, Makaryan V, Beekman R, Behrens K, Stocking C, Obenauer J, Schnittger S, Kohlmann A, Valkhof MG, Hoogenboezem R, Göhring G, Reinhardt D, Schlegelberger B, Stanulla M, Vandenberghe P, Donadieu J, Zwaan CM, Touw IP, van den Heuvel-Eibrink MM, Dale DC, Welte K. Skokowa J, et al. Among authors: klimenkova o. Blood. 2014 Apr 3;123(14):2229-37. doi: 10.1182/blood-2013-11-538025. Epub 2014 Feb 12. Blood. 2014. PMID: 24523240 Free article.
Two cases of cyclic neutropenia with acquired CSF3R mutations, with 1 developing AML.
Klimiankou M, Mellor-Heineke S, Klimenkova O, Reinel E, Uenalan M, Kandabarau S, Skokowa J, Welte K, Zeidler C. Klimiankou M, et al. Among authors: klimenkova o. Blood. 2016 May 26;127(21):2638-41. doi: 10.1182/blood-2015-12-685784. Epub 2016 Mar 30. Blood. 2016. PMID: 27030388 Free article. No abstract available.
Cooperating, congenital neutropenia-associated Csf3r and Runx1 mutations activate pro-inflammatory signaling and inhibit myeloid differentiation of mouse HSPCs.
Ritter M, Klimiankou M, Klimenkova O, Schambach A, Hoffmann D, Schmidt A, Kanz L, Link DC, Welte K, Skokowa J. Ritter M, et al. Among authors: klimenkova o. Ann Hematol. 2020 Oct;99(10):2329-2338. doi: 10.1007/s00277-020-04194-0. Epub 2020 Aug 3. Ann Hematol. 2020. PMID: 32821971 Free PMC article.
Large-scale hematopoietic differentiation of human induced pluripotent stem cells provides granulocytes or macrophages for cell replacement therapies.
Lachmann N, Ackermann M, Frenzel E, Liebhaber S, Brennig S, Happle C, Hoffmann D, Klimenkova O, Lüttge D, Buchegger T, Kühnel MP, Schambach A, Janciauskiene S, Figueiredo C, Hansen G, Skokowa J, Moritz T. Lachmann N, et al. Among authors: klimenkova o. Stem Cell Reports. 2015 Feb 10;4(2):282-96. doi: 10.1016/j.stemcr.2015.01.005. Stem Cell Reports. 2015. PMID: 25680479 Free PMC article.
11 results