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cAMP and Epac in the regulation of tissue fibrosis.
Insel PA, Murray F, Yokoyama U, Romano S, Yun H, Brown L, Snead A, Lu D, Aroonsakool N. Insel PA, et al. Among authors: yokoyama u. Br J Pharmacol. 2012 May;166(2):447-56. doi: 10.1111/j.1476-5381.2012.01847.x. Br J Pharmacol. 2012. PMID: 22233238 Free PMC article. Review.
The cyclic AMP effector Epac integrates pro- and anti-fibrotic signals.
Yokoyama U, Patel HH, Lai NC, Aroonsakool N, Roth DM, Insel PA. Yokoyama U, et al. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6386-91. doi: 10.1073/pnas.0801490105. Epub 2008 Apr 23. Proc Natl Acad Sci U S A. 2008. PMID: 18434542 Free PMC article.
Increased smooth muscle cell expression of caveolin-1 and caveolae contribute to the pathophysiology of idiopathic pulmonary arterial hypertension.
Patel HH, Zhang S, Murray F, Suda RY, Head BP, Yokoyama U, Swaney JS, Niesman IR, Schermuly RT, Pullamsetti SS, Thistlethwaite PA, Miyanohara A, Farquhar MG, Yuan JX, Insel PA. Patel HH, et al. Among authors: yokoyama u. FASEB J. 2007 Sep;21(11):2970-9. doi: 10.1096/fj.07-8424com. Epub 2007 Apr 30. FASEB J. 2007. PMID: 17470567
Cardiac-specific overexpression of caveolin-3 induces endogenous cardiac protection by mimicking ischemic preconditioning.
Tsutsumi YM, Horikawa YT, Jennings MM, Kidd MW, Niesman IR, Yokoyama U, Head BP, Hagiwara Y, Ishikawa Y, Miyanohara A, Patel PM, Insel PA, Patel HH, Roth DM. Tsutsumi YM, et al. Among authors: yokoyama u. Circulation. 2008 Nov 4;118(19):1979-88. doi: 10.1161/CIRCULATIONAHA.108.788331. Epub 2008 Oct 20. Circulation. 2008. PMID: 18936328 Free PMC article.
The role of Epac in the heart.
Fujita T, Umemura M, Yokoyama U, Okumura S, Ishikawa Y. Fujita T, et al. Among authors: yokoyama u. Cell Mol Life Sci. 2017 Feb;74(4):591-606. doi: 10.1007/s00018-016-2336-5. Epub 2016 Aug 22. Cell Mol Life Sci. 2017. PMID: 27549789 Free PMC article. Review.
Epac activation inhibits IL-6-induced cardiac myocyte dysfunction.
Jin H, Fujita T, Jin M, Kurotani R, Hidaka Y, Cai W, Suita K, Prajapati R, Liang C, Ohnuki Y, Mototani Y, Umemura M, Yokoyama U, Sato M, Okumura S, Ishikawa Y. Jin H, et al. Among authors: yokoyama u. J Physiol Sci. 2018 Jan;68(1):77-87. doi: 10.1007/s12576-016-0509-5. Epub 2016 Dec 19. J Physiol Sci. 2018. PMID: 27995459 Free PMC article.
114 results