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Design, synthesis and evaluation of caffeic acid phenethyl ester-based inhibitors targeting a selectivity pocket in the active site of human aldo-keto reductase 1B10.
Soda M, Hu D, Endo S, Takemura M, Li J, Wada R, Ifuku S, Zhao HT, El-Kabbani O, Ohta S, Yamamura K, Toyooka N, Hara A, Matsunaga T. Soda M, et al. Among authors: takemura m. Eur J Med Chem. 2012 Feb;48:321-9. doi: 10.1016/j.ejmech.2011.12.034. Epub 2011 Dec 29. Eur J Med Chem. 2012. PMID: 22236472
Design, synthesis, and biological evaluation of novel (1-thioxo-1,2,3,4-tetrahydro-β-carbolin-9-yl)acetic acids as selective inhibitors for AKR1B1.
Minehira D, Takeda D, Urata H, Kato A, Adachi I, Wang X, Matsuya Y, Sugimoto K, Takemura M, Endo S, Matsunaga T, Hara A, Koseki J, Narukawa K, Hirono S, Toyooka N. Minehira D, et al. Among authors: takemura m. Bioorg Med Chem. 2012 Jan 1;20(1):356-67. doi: 10.1016/j.bmc.2011.10.073. Epub 2011 Nov 3. Bioorg Med Chem. 2012. PMID: 22104435
Protective roles of aldo-keto reductase 1B10 and autophagy against toxicity induced by p-quinone metabolites of tert-butylhydroquinone in lung cancer A549 cells.
Endo S, Nishiyama A, Suyama M, Takemura M, Soda M, Chen H, Tajima K, El-Kabbani O, Bunai Y, Hara A, Matsunaga T, Ikari A. Endo S, et al. Among authors: takemura m. Chem Biol Interact. 2015 Jun 5;234:282-9. doi: 10.1016/j.cbi.2014.09.023. Epub 2014 Oct 5. Chem Biol Interact. 2015. PMID: 25289770
Cleavage of Hsp70.1 causes lysosomal cell death under stress conditions.
Yamashima T, Mochly-Rosen D, Wakatsuki S, Mizukoshi E, Seike T, Larus IM, Chen CH, Takemura M, Saito H, Ohashi A. Yamashima T, et al. Among authors: takemura m. Front Mol Biosci. 2024 May 27;11:1378656. doi: 10.3389/fmolb.2024.1378656. eCollection 2024. Front Mol Biosci. 2024. PMID: 38859931 Free PMC article. Review.
1,008 results