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Identification and preliminary characterization of a potent, safe, and orally efficacious inhibitor of acyl-CoA:diacylglycerol acyltransferase 1.
Yeh VS, Beno DW, Brodjian S, Brune ME, Cullen SC, Dayton BD, Dhaon MK, Falls HD, Gao J, Grihalde N, Hajduk P, Hansen TM, Judd AS, King AJ, Klix RC, Larson KJ, Lau YY, Marsh KC, Mittelstadt SW, Plata D, Rozema MJ, Segreti JA, Stoner EJ, Voorbach MJ, Wang X, Xin X, Zhao G, Collins CA, Cox BF, Reilly RM, Kym PR, Souers AJ. Yeh VS, et al. Among authors: larson kj. J Med Chem. 2012 Feb 23;55(4):1751-7. doi: 10.1021/jm201524g. Epub 2012 Feb 10. J Med Chem. 2012. PMID: 22263872
Effect of the multitargeted receptor tyrosine kinase inhibitor, ABT-869 [N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea], on blood pressure in conscious rats and mice: reversal with antihypertensive agents and effect on tumor growth inhibition.
Franklin PH, Banfor PN, Tapang P, Segreti JA, Widomski DL, Larson KJ, Noonan WT, Gintant GA, Davidsen SK, Albert DH, Fryer RM, Cox BF. Franklin PH, et al. Among authors: larson kj. J Pharmacol Exp Ther. 2009 Jun;329(3):928-37. doi: 10.1124/jpet.108.144816. Epub 2009 Mar 2. J Pharmacol Exp Ther. 2009. PMID: 19255283
Discovery of A-971432, An Orally Bioavailable Selective Sphingosine-1-Phosphate Receptor 5 (S1P5) Agonist for the Potential Treatment of Neurodegenerative Disorders.
Hobson AD, Harris CM, van der Kam EL, Turner SC, Abibi A, Aguirre AL, Bousquet P, Kebede T, Konopacki DB, Gintant G, Kim Y, Larson K, Maull JW, Moore NS, Shi D, Shrestha A, Tang X, Zhang P, Sarris KK. Hobson AD, et al. J Med Chem. 2015 Dec 10;58(23):9154-70. doi: 10.1021/acs.jmedchem.5b00928. Epub 2015 Nov 23. J Med Chem. 2015. PMID: 26509640
Pharmacological comparison of peristaltic effects in rats and mice.
Shaughnessy TK, Larson KJ, Polakowski JS, Martin RL. Shaughnessy TK, et al. Among authors: larson kj. J Pharmacol Toxicol Methods. 2013 May-Jun;67(3):129-33. doi: 10.1016/j.vascn.2013.02.001. Epub 2013 Feb 8. J Pharmacol Toxicol Methods. 2013. PMID: 23403246
Chokeberry reduces inflammation in human preadipocytes.
Brunelle DC, Larson KJ, Bundy A, Roemmich JN, Warne D, Redvers N. Brunelle DC, et al. Among authors: larson kj. J Funct Foods. 2024 Jan;112:105947. doi: 10.1016/j.jff.2023.105947. Epub 2023 Dec 15. J Funct Foods. 2024. PMID: 38644957 Free PMC article.
Incorporating the Dietary Guidelines for Americans Vegetable Recommendations into the Diet Alters Dietary Intake Patterns of Other Foods and Improves Diet Quality in Adults with Overweight and Obesity.
Casperson SL, Jahns L, Duke SE, Nelson AM, Appleton KM, Larson KJ, Roemmich JN. Casperson SL, et al. Among authors: larson kj. J Acad Nutr Diet. 2022 Jul;122(7):1345-1354.e1. doi: 10.1016/j.jand.2022.03.008. Epub 2022 Mar 9. J Acad Nutr Diet. 2022. PMID: 35278698 Clinical Trial.
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