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542 results

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Page 1
Discovery of potent and selective covalent inhibitors of JNK.
Zhang T, Inesta-Vaquera F, Niepel M, Zhang J, Ficarro SB, Machleidt T, Xie T, Marto JA, Kim N, Sim T, Laughlin JD, Park H, LoGrasso PV, Patricelli M, Nomanbhoy TK, Sorger PK, Alessi DR, Gray NS. Zhang T, et al. Among authors: gray ns. Chem Biol. 2012 Jan 27;19(1):140-54. doi: 10.1016/j.chembiol.2011.11.010. Chem Biol. 2012. PMID: 22284361 Free PMC article.
Allosteric inhibitors of Bcr-abl-dependent cell proliferation.
Adrián FJ, Ding Q, Sim T, Velentza A, Sloan C, Liu Y, Zhang G, Hur W, Ding S, Manley P, Mestan J, Fabbro D, Gray NS. Adrián FJ, et al. Among authors: gray ns. Nat Chem Biol. 2006 Feb;2(2):95-102. doi: 10.1038/nchembio760. Epub 2006 Jan 15. Nat Chem Biol. 2006. PMID: 16415863
A general strategy for creating "inactive-conformation" abl inhibitors.
Okram B, Nagle A, Adrián FJ, Lee C, Ren P, Wang X, Sim T, Xie Y, Wang X, Xia G, Spraggon G, Warmuth M, Liu Y, Gray NS. Okram B, et al. Among authors: gray ns. Chem Biol. 2006 Jul;13(7):779-86. doi: 10.1016/j.chembiol.2006.05.015. Chem Biol. 2006. PMID: 16873026
Discovery of pyrimidine benzimidazoles as Lck inhibitors: part I.
Zhang G, Ren P, Gray NS, Sim T, Liu Y, Wang X, Che J, Tian SS, Sandberg ML, Spalding TA, Romeo R, Iskandar M, Chow D, Martin Seidel H, Karanewsky DS, He Y. Zhang G, et al. Among authors: gray ns. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5618-21. doi: 10.1016/j.bmcl.2008.08.104. Epub 2008 Aug 31. Bioorg Med Chem Lett. 2008. PMID: 18793846
Conformational disturbance in Abl kinase upon mutation and deregulation.
Iacob RE, Pene-Dumitrescu T, Zhang J, Gray NS, Smithgall TE, Engen JR. Iacob RE, et al. Among authors: gray ns. Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1386-91. doi: 10.1073/pnas.0811912106. Epub 2009 Jan 21. Proc Natl Acad Sci U S A. 2009. PMID: 19164531 Free PMC article.
Discovery and structural analysis of Eph receptor tyrosine kinase inhibitors.
Choi Y, Syeda F, Walker JR, Finerty PJ Jr, Cuerrier D, Wojciechowski A, Liu Q, Dhe-Paganon S, Gray NS. Choi Y, et al. Among authors: gray ns. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4467-70. doi: 10.1016/j.bmcl.2009.05.029. Epub 2009 May 13. Bioorg Med Chem Lett. 2009. PMID: 19553108 Free PMC article.
542 results