Bate N - Search Results

1

New isoform-specific monoclonal antibodies reveal different sub-cellular localisations for talin1 and talin2.

Praekelt U, Kopp PM, Rehm K, Linder S, Bate N, Patel B, Debrand E, Manso AM, Ross RS, Conti F, Zhang MZ, Harris RC, Zent R, Critchley DR, Monkley SJ. Praekelt U, et al. Among authors: bate n. Eur J Cell Biol. 2012 Mar;91(3):180-91. doi: 10.1016/j.ejcb.2011.12.003. Epub 2012 Feb 3. Eur J Cell Biol. 2012. PMID: 22306379 Free PMC article.

2

Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1.

Kopp PM, Bate N, Hansen TM, Brindle NP, Praekelt U, Debrand E, Coleman S, Mazzeo D, Goult BT, Gingras AR, Pritchard CA, Critchley DR, Monkley SJ. Kopp PM, et al. Among authors: bate n. Eur J Cell Biol. 2010 Sep;89(9):661-73. doi: 10.1016/j.ejcb.2010.05.003. Eur J Cell Biol. 2010. PMID: 20605055 Free PMC article.

3

Structural studies on full-length talin1 reveal a compact auto-inhibited dimer: implications for talin activation.

Goult BT, Xu XP, Gingras AR, Swift M, Patel B, Bate N, Kopp PM, Barsukov IL, Critchley DR, Volkmann N, Hanein D. Goult BT, et al. Among authors: bate n. J Struct Biol. 2013 Oct;184(1):21-32. doi: 10.1016/j.jsb.2013.05.014. Epub 2013 May 30. J Struct Biol. 2013. PMID: 23726984 Free PMC article.

4

Talin 2 is a large and complex gene encoding multiple transcripts and protein isoforms.

Debrand E, El Jai Y, Spence L, Bate N, Praekelt U, Pritchard CA, Monkley SJ, Critchley DR. Debrand E, et al. Among authors: bate n. FEBS J. 2009 Mar;276(6):1610-28. doi: 10.1111/j.1742-4658.2009.06893.x. Epub 2009 Feb 7. FEBS J. 2009. PMID: 19220457 Free PMC article.

5

The structure of the N-terminus of kindlin-1: a domain important for alphaiibbeta3 integrin activation.

Goult BT, Bouaouina M, Harburger DS, Bate N, Patel B, Anthis NJ, Campbell ID, Calderwood DA, Barsukov IL, Roberts GC, Critchley DR. Goult BT, et al. Among authors: bate n. J Mol Biol. 2009 Dec 18;394(5):944-56. doi: 10.1016/j.jmb.2009.09.061. Epub 2009 Oct 3. J Mol Biol. 2009. PMID: 19804783 Free PMC article.

6

Central region of talin has a unique fold that binds vinculin and actin.

Gingras AR, Bate N, Goult BT, Patel B, Kopp PM, Emsley J, Barsukov IL, Roberts GC, Critchley DR. Gingras AR, et al. Among authors: bate n. J Biol Chem. 2010 Sep 17;285(38):29577-87. doi: 10.1074/jbc.M109.095455. Epub 2010 Jul 7. J Biol Chem. 2010. PMID: 20610383 Free PMC article.

7

Talin contains a C-terminal calpain2 cleavage site important in focal adhesion dynamics.

Bate N, Gingras AR, Bachir A, Horwitz R, Ye F, Patel B, Goult BT, Critchley DR. Bate N, et al. PLoS One. 2012;7(4):e34461. doi: 10.1371/journal.pone.0034461. Epub 2012 Apr 4. PLoS One. 2012. PMID: 22496808 Free PMC article.

8

Mice carrying a complete deletion of the talin2 coding sequence are viable and fertile.

Debrand E, Conti FJ, Bate N, Spence L, Mazzeo D, Pritchard CA, Monkley SJ, Critchley DR. Debrand E, et al. Among authors: bate n. Biochem Biophys Res Commun. 2012 Sep 21;426(2):190-5. doi: 10.1016/j.bbrc.2012.08.061. Epub 2012 Aug 17. Biochem Biophys Res Commun. 2012. PMID: 22925892 Free PMC article.

9

Vinculin controls talin engagement with the actomyosin machinery.

Atherton P, Stutchbury B, Wang DY, Jethwa D, Tsang R, Meiler-Rodriguez E, Wang P, Bate N, Zent R, Barsukov IL, Goult BT, Critchley DR, Ballestrem C. Atherton P, et al. Among authors: bate n. Nat Commun. 2015 Dec 4;6:10038. doi: 10.1038/ncomms10038. Nat Commun. 2015. PMID: 26634421 Free PMC article.

10

Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle.

Papagrigoriou E, Gingras AR, Barsukov IL, Bate N, Fillingham IJ, Patel B, Frank R, Ziegler WH, Roberts GC, Critchley DR, Emsley J. Papagrigoriou E, et al. Among authors: bate n. EMBO J. 2004 Aug 4;23(15):2942-51. doi: 10.1038/sj.emboj.7600285. Epub 2004 Jul 22. EMBO J. 2004. PMID: 15272303 Free PMC article.

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