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EMILIN-3, peculiar member of elastin microfibril interface-located protein (EMILIN) family, has distinct expression pattern, forms oligomeric assemblies, and serves as transforming growth factor β (TGF-β) antagonist.
Schiavinato A, Becker AK, Zanetti M, Corallo D, Milanetto M, Bizzotto D, Bressan G, Guljelmovic M, Paulsson M, Wagener R, Braghetta P, Bonaldo P. Schiavinato A, et al. Among authors: bressan g. J Biol Chem. 2012 Mar 30;287(14):11498-515. doi: 10.1074/jbc.M111.303578. Epub 2012 Feb 10. J Biol Chem. 2012. PMID: 22334695 Free PMC article.
Multimerin-2 maintains vascular stability and permeability.
Pellicani R, Poletto E, Andreuzzi E, Paulitti A, Doliana R, Bizzotto D, Braghetta P, Colladel R, Tarticchio G, Sabatelli P, Bucciotti F, Bressan G, Iozzo RV, Colombatti A, Bonaldo P, Mongiat M. Pellicani R, et al. Among authors: bressan g. Matrix Biol. 2020 May;87:11-25. doi: 10.1016/j.matbio.2019.08.002. Epub 2019 Aug 15. Matrix Biol. 2020. PMID: 31422156 Free article.
Expression of the EMILIN-1 gene during mouse development.
Braghetta P, Ferrari A, de Gemmis P, Zanetti M, Volpin D, Bonaldo P, Bressan GM. Braghetta P, et al. Matrix Biol. 2002 Nov;21(7):603-9. doi: 10.1016/s0945-053x(02)00072-0. Matrix Biol. 2002. PMID: 12475644
EMILIN-1 deficiency induces elastogenesis and vascular cell defects.
Zanetti M, Braghetta P, Sabatelli P, Mura I, Doliana R, Colombatti A, Volpin D, Bonaldo P, Bressan GM. Zanetti M, et al. Mol Cell Biol. 2004 Jan;24(2):638-50. doi: 10.1128/MCB.24.2.638-650.2004. Mol Cell Biol. 2004. PMID: 14701737 Free PMC article.
Vascular smooth muscle Emilin-1 is a regulator of arteriolar myogenic response and blood pressure.
Litteri G, Carnevale D, D'Urso A, Cifelli G, Braghetta P, Damato A, Bizzotto D, Landolfi A, Ros FD, Sabatelli P, Facchinello N, Maffei A, Volpin D, Colombatti A, Bressan GM, Lembo G. Litteri G, et al. Among authors: bressan gm. Arterioscler Thromb Vasc Biol. 2012 Sep;32(9):2178-84. doi: 10.1161/ATVBAHA.112.254664. Epub 2012 Jul 19. Arterioscler Thromb Vasc Biol. 2012. PMID: 22814752
Loss of EMILIN-1 Enhances Arteriolar Myogenic Tone Through TGF-β (Transforming Growth Factor-β)-Dependent Transactivation of EGFR (Epidermal Growth Factor Receptor) and Is Relevant for Hypertension in Mice and Humans.
Carnevale D, Facchinello N, Iodice D, Bizzotto D, Perrotta M, De Stefani D, Pallante F, Carnevale L, Ricciardi F, Cifelli G, Da Ros F, Casaburo M, Fardella S, Bonaldo P, Innocenzi G, Rizzuto R, Braghetta P, Lembo G, Bressan GM. Carnevale D, et al. Among authors: bressan gm. Arterioscler Thromb Vasc Biol. 2018 Oct;38(10):2484-2497. doi: 10.1161/ATVBAHA.118.311115. Arterioscler Thromb Vasc Biol. 2018. PMID: 30354220
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