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CREMα overexpression decreases IL-2 production, induces a T(H)17 phenotype and accelerates autoimmunity.
Lippe R, Ohl K, Varga G, Rauen T, Crispin JC, Juang YT, Kuerten S, Tacke F, Wolf M, Roebrock K, Vogl T, Verjans E, Honke N, Ehrchen J, Foell D, Skryabin B, Wagner N, Tsokos GC, Roth J, Tenbrock K. Lippe R, et al. Among authors: juang yt. J Mol Cell Biol. 2012 Apr;4(2):121-3. doi: 10.1093/jmcb/mjs004. Epub 2012 Feb 20. J Mol Cell Biol. 2012. PMID: 22355096 No abstract available.
A novel intronic cAMP response element modulator (CREM) promoter is regulated by activator protein-1 (AP-1) and accounts for altered activation-induced CREM expression in T cells from patients with systemic lupus erythematosus.
Rauen T, Benedyk K, Juang YT, Kerkhoff C, Kyttaris VC, Roth J, Tsokos GC, Tenbrock K. Rauen T, et al. Among authors: juang yt. J Biol Chem. 2011 Sep 16;286(37):32366-72. doi: 10.1074/jbc.M111.245811. Epub 2011 Jul 13. J Biol Chem. 2011. PMID: 21757709 Free PMC article.
59 results