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Structure of human ADAM-8 catalytic domain complexed with batimastat.
Hall T, Shieh HS, Day JE, Caspers N, Chrencik JE, Williams JM, Pegg LE, Pauley AM, Moon AF, Krahn JM, Fischer DH, Kiefer JR, Tomasselli AG, Zack MD. Hall T, et al. Among authors: shieh hs. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jun 1;68(Pt 6):616-21. doi: 10.1107/S1744309112015618. Epub 2012 May 22. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012. PMID: 22684055 Free PMC article.
High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2).
Shieh HS, Mathis KJ, Williams JM, Hills RL, Wiese JF, Benson TE, Kiefer JR, Marino MH, Carroll JN, Leone JW, Malfait AM, Arner EC, Tortorella MD, Tomasselli A. Shieh HS, et al. J Biol Chem. 2008 Jan 18;283(3):1501-1507. doi: 10.1074/jbc.M705879200. Epub 2007 Nov 8. J Biol Chem. 2008. PMID: 17991750 Free article.
Structure analysis reveals the flexibility of the ADAMTS-5 active site.
Shieh HS, Tomasselli AG, Mathis KJ, Schnute ME, Woodard SS, Caspers N, Williams JM, Kiefer JR, Munie G, Wittwer A, Malfait AM, Tortorella MD. Shieh HS, et al. Protein Sci. 2011 Apr;20(4):735-44. doi: 10.1002/pro.606. Protein Sci. 2011. PMID: 21370305 Free PMC article.
Synthesis, crystal structure, and activity of pyrazole-based inhibitors of p38 kinase.
Graneto MJ, Kurumbail RG, Vazquez ML, Shieh HS, Pawlitz JL, Williams JM, Stallings WC, Geng L, Naraian AS, Koszyk FJ, Stealey MA, Xu XD, Weier RM, Hanson GJ, Mourey RJ, Compton RP, Mnich SJ, Anderson GD, Monahan JB, Devraj R. Graneto MJ, et al. Among authors: shieh hs. J Med Chem. 2007 Nov 15;50(23):5712-9. doi: 10.1021/jm0611915. Epub 2007 Oct 19. J Med Chem. 2007. PMID: 17948975
Identification of the high affinity binding site in transforming growth factor-beta involved in complex formation with alpha 2-macroglobulin. Implications regarding the molecular mechanisms of complex formation between alpha 2-macroglobulin and growth factors, cytokines, and hormones.
Liu Q, Ling TY, Shieh HS, Johnson FE, Huang JS, Huang SS. Liu Q, et al. Among authors: shieh hs. J Biol Chem. 2001 Dec 7;276(49):46212-8. doi: 10.1074/jbc.M105177200. Epub 2001 Oct 2. J Biol Chem. 2001. PMID: 11583997 Free article.
41 results