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A hypomorphic mutation in the Gfi1 transcriptional repressor results in a novel form of neutropenia.
Ordoñez-Rueda D, Jönsson F, Mancardi DA, Zhao W, Malzac A, Liang Y, Bertosio E, Grenot P, Blanquet V, Sabrautzki S, de Angelis MH, Méresse S, Duprez E, Bruhns P, Malissen B, Malissen M. Ordoñez-Rueda D, et al. Among authors: bruhns p. Eur J Immunol. 2012 Sep;42(9):2395-408. doi: 10.1002/eji.201242589. Eur J Immunol. 2012. PMID: 22684987 Free article.
Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines.
Scepanovic P, Alanio C, Hammer C, Hodel F, Bergstedt J, Patin E, Thorball CW, Chaturvedi N, Charbit B, Abel L, Quintana-Murci L, Duffy D, Albert ML, Fellay J; Milieu Intérieur Consortium. Scepanovic P, et al. Genome Med. 2018 Jul 27;10(1):59. doi: 10.1186/s13073-018-0568-8. Genome Med. 2018. PMID: 30053915 Free PMC article. Clinical Trial.
Sec22b is a critical and nonredundant regulator of plasma cell maintenance.
Bonaud A, Gargowitsch L, Gilbert SM, Rajan E, Canales-Herrerias P, Stockholm D, Rahman NF, Collins MO, Taskiran H, Hill DL, Alloatti A, Alouche N, Balor S, Soldan V, Gillet D, Barbier J, Bachelerie F, Smith KGC, Jellusova J, Bruhns P, Amigorena S, Balabanian K, Linterman MA, Peden AA, Espéli M. Bonaud A, et al. Among authors: bruhns p. Proc Natl Acad Sci U S A. 2023 Jan 10;120(2):e2213056120. doi: 10.1073/pnas.2213056120. Epub 2023 Jan 3. Proc Natl Acad Sci U S A. 2023. PMID: 36595686 Free PMC article.
Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges.
Piasecka B, Duffy D, Urrutia A, Quach H, Patin E, Posseme C, Bergstedt J, Charbit B, Rouilly V, MacPherson CR, Hasan M, Albaud B, Gentien D, Fellay J, Albert ML, Quintana-Murci L; Milieu Intérieur Consortium. Piasecka B, et al. Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):E488-E497. doi: 10.1073/pnas.1714765115. Epub 2017 Dec 27. Proc Natl Acad Sci U S A. 2018. PMID: 29282317 Free PMC article.
A comprehensive assessment of demographic, environmental, and host genetic associations with gut microbiome diversity in healthy individuals.
Scepanovic P, Hodel F, Mondot S, Partula V, Byrd A, Hammer C, Alanio C, Bergstedt J, Patin E, Touvier M, Lantz O, Albert ML, Duffy D, Quintana-Murci L, Fellay J; Milieu Intérieur Consortium. Scepanovic P, et al. Microbiome. 2019 Sep 13;7(1):130. doi: 10.1186/s40168-019-0747-x. Microbiome. 2019. PMID: 31519223 Free PMC article.
Mouse and human neutrophils induce anaphylaxis.
Jönsson F, Mancardi DA, Kita Y, Karasuyama H, Iannascoli B, Van Rooijen N, Shimizu T, Daëron M, Bruhns P. Jönsson F, et al. Among authors: bruhns p. J Clin Invest. 2011 Apr;121(4):1484-96. doi: 10.1172/JCI45232. Epub 2011 Mar 23. J Clin Invest. 2011. PMID: 21436586 Free PMC article.
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