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Synthesis of 2-(pyridin-3-yl)-1-azabicyclo[3.2.2]nonane, 2-(pyridin-3-yl)-1-azabicyclo[2.2.2]octane, and 2-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, a class of potent nicotinic acetylcholine receptor-ligands.
Bhatti BS, Strachan JP, Breining SR, Miller CH, Tahiri P, Crooks PA, Deo N, Day CS, Caldwell WS. Bhatti BS, et al. Among authors: strachan jp. J Org Chem. 2008 May 2;73(9):3497-507. doi: 10.1021/jo800028q. Epub 2008 Mar 26. J Org Chem. 2008. PMID: 18363376
Discovery of 3-(5-chloro-2-furoyl)-3,7-diazabicyclo[3.3.0]octane (TC-6683, AZD1446), a novel highly selective α4β2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders.
Mazurov AA, Miao L, Bhatti BS, Strachan JP, Akireddy S, Murthy S, Kombo D, Xiao YD, Hammond P, Zhang J, Hauser TA, Jordan KG, Miller CH, Speake JD, Gatto GJ, Yohannes D. Mazurov AA, et al. Among authors: strachan jp. J Med Chem. 2012 Nov 8;55(21):9181-94. doi: 10.1021/jm3006542. Epub 2012 Jul 27. J Med Chem. 2012. PMID: 22793665
Identification and pharmacological characterization of 3,6-diazabicyclo[3.1.1]heptane-3-carboxamides as novel ligands for the α4β2 and α6/α3β2β3 nicotinic acetylcholine receptors (nAChRs).
Strachan JP, Kombo DC, Mazurov A, Heemstra R, Bhatti BS, Akireddy R, Murthy S, Miao L, Jett JE, Speake J, Bencherif M. Strachan JP, et al. Eur J Med Chem. 2014 Oct 30;86:60-74. doi: 10.1016/j.ejmech.2014.08.019. Epub 2014 Aug 7. Eur J Med Chem. 2014. PMID: 25147147
Synthesis of bicyclic tertiary alpha-amino acids.
Strachan JP, Whitaker RC, Miller CH, Bhatti BS. Strachan JP, et al. J Org Chem. 2006 Dec 22;71(26):9909-11. doi: 10.1021/jo061977a. J Org Chem. 2006. PMID: 17168622
Pharmacological properties and predicted binding mode of arylmethylene quinuclidine-like derivatives at the α3β4 nicotinic acetylcholine receptor (nAChR).
Kombo DC, Hauser TA, Grinevich VP, Melvin MS, Strachan JP, Sidach SS, Chewning J, Fedorov N, Tallapragada K, Breining SR, Miller CH. Kombo DC, et al. Among authors: strachan jp. Bioorg Med Chem Lett. 2013 Mar 1;23(5):1450-5. doi: 10.1016/j.bmcl.2012.12.054. Epub 2012 Dec 28. Bioorg Med Chem Lett. 2013. PMID: 23352509
Discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent, selective and orally active antitumor agents.
Huang KH, Veal JM, Fadden RP, Rice JW, Eaves J, Strachan JP, Barabasz AF, Foley BE, Barta TE, Ma W, Silinski MA, Hu M, Partridge JM, Scott A, DuBois LG, Freed T, Steed PM, Ommen AJ, Smith ED, Hughes PF, Woodward AR, Hanson GJ, McCall WS, Markworth CJ, Hinkley L, Jenks M, Geng L, Lewis M, Otto J, Pronk B, Verleysen K, Hall SE. Huang KH, et al. Among authors: strachan jp. J Med Chem. 2009 Jul 23;52(14):4288-305. doi: 10.1021/jm900230j. J Med Chem. 2009. PMID: 19552433
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