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Novel potent and selective calcium-release-activated calcium (CRAC) channel inhibitors. Part 1: synthesis and inhibitory activity of 5-(1-methyl-3-trifluoromethyl-1H-pyrazol-5-yl)-2-thiophenecarboxamides.
Yonetoku Y, Kubota H, Okamoto Y, Toyoshima A, Funatsu M, Ishikawa J, Takeuchi M, Ohta M, Tsukamoto S. Yonetoku Y, et al. Among authors: kubota h. Bioorg Med Chem. 2006 Jul 15;14(14):4750-60. doi: 10.1016/j.bmc.2006.03.024. Epub 2006 Mar 31. Bioorg Med Chem. 2006. PMID: 16580212
Synthesis and structure-activity relationships of N-{1-[(6-fluoro-2-naphthyl)methyl]piperidin-4-yl}benzamide derivatives as novel CCR3 antagonists.
Sato I, Morihira K, Inami H, Kubota H, Morokata T, Suzuki K, Hamada N, Iura Y, Nitta A, Imaoka T, Takahashi T, Takeuchi M, Ohta M, Tsukamoto S. Sato I, et al. Among authors: kubota h. Bioorg Med Chem. 2008 Jan 1;16(1):144-56. doi: 10.1016/j.bmc.2007.10.003. Epub 2007 Oct 5. Bioorg Med Chem. 2008. PMID: 17951061
Pyrrolidinyl phenylurea derivatives as novel CCR3 antagonists.
Nitta A, Iura Y, Inoue H, Sato I, Morihira K, Kubota H, Morokata T, Takeuchi M, Ohta M, Tsukamoto S, Imaoka T, Takahashi T. Nitta A, et al. Among authors: kubota h. Bioorg Med Chem Lett. 2012 Nov 15;22(22):6876-81. doi: 10.1016/j.bmcl.2012.09.035. Epub 2012 Sep 20. Bioorg Med Chem Lett. 2012. PMID: 23046963
Novel potent and selective Ca2+ release-activated Ca2+ (CRAC) channel inhibitors. Part 3: synthesis and CRAC channel inhibitory activity of 4'-[(trifluoromethyl)pyrazol-1-yl]carboxanilides.
Yonetoku Y, Kubota H, Miyazaki Y, Okamoto Y, Funatsu M, Yoshimura-Ishikawa N, Ishikawa J, Yoshino T, Takeuchi M, Ohta M. Yonetoku Y, et al. Among authors: kubota h. Bioorg Med Chem. 2008 Nov 1;16(21):9457-66. doi: 10.1016/j.bmc.2008.09.047. Epub 2008 Sep 20. Bioorg Med Chem. 2008. PMID: 18835179
Identification, synthesis, and biological evaluation of 6-[(6R)-2-(4-fluorophenyl)-6-(hydroxymethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2-(2-methylphenyl)pyridazin-3(2H)-one (AS1940477), a potent p38 MAP kinase inhibitor.
Asano T, Yamazaki H, Kasahara C, Kubota H, Kontani T, Harayama Y, Ohno K, Mizuhara H, Yokomoto M, Misumi K, Kinoshita T, Ohta M, Takeuchi M. Asano T, et al. Among authors: kubota h. J Med Chem. 2012 Sep 13;55(17):7772-85. doi: 10.1021/jm3008008. Epub 2012 Aug 31. J Med Chem. 2012. PMID: 22905713
1,354 results