Trapani JA - Search Results

1

Granzyme B is dispensable in the development of diabetes in non-obese diabetic mice.

Mollah ZU, Graham KL, Krishnamurthy B, Trivedi P, Brodnicki TC, Trapani JA, Kay TW, Thomas HE. Mollah ZU, et al. Among authors: trapani ja. PLoS One. 2012;7(7):e40357. doi: 10.1371/journal.pone.0040357. Epub 2012 Jul 9. PLoS One. 2012. PMID: 22792290 Free PMC article.

2

A critical role for granzyme B, in addition to perforin and TNFalpha, in alloreactive CTL-induced mouse pancreatic beta cell death.

Sutton VR, Estella E, Li C, Chen M, Thomas HE, Kay TW, Trapani JA. Sutton VR, et al. Among authors: trapani ja. Transplantation. 2006 Jan 27;81(2):146-54. doi: 10.1097/01.tp.0000191939.68451.d9. Transplantation. 2006. PMID: 16436955

3

Perforin and Fas induced by IFNgamma and TNFalpha mediate beta cell death by OT-I CTL.

McKenzie MD, Dudek NL, Mariana L, Chong MM, Trapani JA, Kay TW, Thomas HE. McKenzie MD, et al. Among authors: trapani ja. Int Immunol. 2006 Jun;18(6):837-46. doi: 10.1093/intimm/dxl020. Epub 2006 Mar 30. Int Immunol. 2006. PMID: 16574667

4

Granzyme B-mediated death of pancreatic beta-cells requires the proapoptotic BH3-only molecule bid.

Estella E, McKenzie MD, Catterall T, Sutton VR, Bird PI, Trapani JA, Kay TW, Thomas HE. Estella E, et al. Among authors: trapani ja. Diabetes. 2006 Aug;55(8):2212-9. doi: 10.2337/db06-0129. Diabetes. 2006. PMID: 16873683

5

Cytotoxic T-cells from T-cell receptor transgenic NOD8.3 mice destroy beta-cells via the perforin and Fas pathways.

Dudek NL, Thomas HE, Mariana L, Sutherland RM, Allison J, Estella E, Angstetra E, Trapani JA, Santamaria P, Lew AM, Kay TW. Dudek NL, et al. Among authors: trapani ja. Diabetes. 2006 Sep;55(9):2412-8. doi: 10.2337/db06-0109. Diabetes. 2006. PMID: 16936188

6

Granzyme K expressing cytotoxic T lymphocytes protects against influenza virus in granzyme AB-/- mice.

Jenkins MR, Trapani JA, Doherty PC, Turner SJ. Jenkins MR, et al. Among authors: trapani ja. Viral Immunol. 2008 Sep;21(3):341-6. doi: 10.1089/vim.2008.0036. Viral Immunol. 2008. PMID: 18788942

7

The role of perforin and granzymes in diabetes.

Thomas HE, Trapani JA, Kay TW. Thomas HE, et al. Among authors: trapani ja. Cell Death Differ. 2010 Apr;17(4):577-85. doi: 10.1038/cdd.2009.165. Epub 2009 Nov 20. Cell Death Differ. 2010. PMID: 19927156 Review.

8

Cathepsin H is an additional convertase of pro-granzyme B.

D'Angelo ME, Bird PI, Peters C, Reinheckel T, Trapani JA, Sutton VR. D'Angelo ME, et al. Among authors: trapani ja. J Biol Chem. 2010 Jul 2;285(27):20514-9. doi: 10.1074/jbc.M109.094573. Epub 2010 Apr 30. J Biol Chem. 2010. PMID: 20435891 Free PMC article.

9

Activated mouse B cells lack expression of granzyme B.

Hagn M, Belz GT, Kallies A, Sutton VR, Thia KY, Tarlinton DM, Hawkins ED, Trapani JA. Hagn M, et al. Among authors: trapani ja. J Immunol. 2012 Apr 15;188(8):3886-92. doi: 10.4049/jimmunol.1103285. Epub 2012 Mar 16. J Immunol. 2012. PMID: 22427643

10

Granzyme A Deficiency Breaks Immune Tolerance and Promotes Autoimmune Diabetes Through a Type I Interferon-Dependent Pathway.

Mollah ZUA, Quah HS, Graham KL, Jhala G, Krishnamurthy B, Dharma JFM, Chee J, Trivedi PM, Pappas EG, Mackin L, Chu EPF, Akazawa S, Fynch S, Hodson C, Deans AJ, Trapani JA, Chong MMW, Bird PI, Brodnicki TC, Thomas HE, Kay TWH. Mollah ZUA, et al. Among authors: trapani ja. Diabetes. 2017 Dec;66(12):3041-3050. doi: 10.2337/db17-0517. Epub 2017 Jul 21. Diabetes. 2017. PMID: 28733313

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